Disease-information

Combination of Terbinafine twice daily and Itraconazole twice in a pulse dose in resistant Tinea infection
International Journal of Research in Dermatology: March, 2022Tinea caused by trichophyton,    microsporum,    and epidermophyton is the most common fungal infection affecting   20–25%   population globally,   with varying geographic distribution.Due to  Bangladesh’s hot and humid cli...
Outcomes of Using Cefepime vs Piperacillin–Tazobactam in Adults Hospitalized with Acute Infection
JAMA: The Journal of the American Medical Association: October, 2023Cefepime and piperacillin-tazobactam are commonly administered to hospitalized adults for empirical treatment of infection. Although piperacillin-tazobactam has been hypothesized to cause acute kidney injury and cefepime has been hypothesized to cause neurological dysfunction,...
Effectiveness of Luliconazole for the Treatment of Tinea Infections
The prevalence of superficial fungal infections across the globe is increasing from 20-25%. Superficial infections are mostly caused by dermatophytes. Depending on the site affected, the dermatophytes are clinically classified as Tinea capitis (head), Tinea faciei (face), Tinea barbae (beard), Tinea manus (hand), Tinea corporis (body), Tinea c...
Effect of Initial Treatment with Quadpill vs Standard Dose Monotherapy in Patients with Hypertension
Circulation: AHA Journals: Published July, 2023Hypertension management remains suboptimal globally, with treatment inertia being identified as one of the main barriers to achieving blood pressure (BP) control. Simpler approaches to achieve target BP levels are needed. TAKE-HOME MESSAGEThe QUARTET study examined the effectiveness of a quadrupl...
Association of Proton Pump Inhibitor Use with the Risk of Kidney Stones
BMJ Open: Published, October, 2023This study aimed to investigate the potential association between PPI use and kidney stones by analysing National Health and Nutrition Examination Survey (NHANES) data from 2007 to 2018. TAKE-HOME MESSAGEThe authors of this large US-based cross-sectional study found that proton-pump inhibitor (PPI) use was asso...
Chlorhexidine Mouthwash Use Twice Weekly for 30 Days Improves Periodontal Status
American Journal of Orthodontics and Dentofacial Orthopedics: Published: August 29, 2023TAKE-HOME MESSAGEThis study showed that, in patients with fixed orthodontic appliances, twice weekly use of 0.12% chlorhexidine (CHX) mouthwash reduced the plaque, gingival, and gingival bleeding indexes when evaluated at 15, 30, and 60 days of protocol imp...
Oral Medications to Treat Toenail Fungal Infection
JAMA: The Journal of the American Medical AssociationThe authors investigated different oral antifungal medications used to treat toenail fungal infections.TAKE-HOME MESSAGECompared with placebo, high-quality evidence supports better clinical (ie, normal appearance of the toenail) and mycological (negative culture, microscopy, or both) results...
The unprecedented epidemic-like scenario of Dermatophytosis: Antifungal resistance and treatment options
There has been a significant increase in the incidence of chronic, relapsing, recurrent cases of superficial dermatophytosis in India that are also often unresponsive to conventional drugs and doses of recommended antifungal treatment. Almost 15– 20% of the outpatient department cases are those of chronic dermatophytosis. Recurrences and relaps...
Disease X: A hidden but inevitable creeping danger
What is Disease X?According to the World Health Organization (WHO), “Disease X represents the knowledge that a serious international epidemic could be caused by a pathogen currently unknown to cause human disease.According to a UK health expert, Disease X could lead to another pandemic more lethal than Covid-19 and could claim at least 50 mill...
Elevated Risk of Developing Type 2 Diabetes in People with Psychiatric Disorders
Journal of Diabetes and its Complications: August 2023Nearly one out of three individuals will develop a psychiatric disorder during their life. Severe psychiatric disorders are associated with higher mortality rates, with 10–20 life-years lost compared to individuals without a severe psychiatric disorderSeveral psychiatric disorders are li...
Therapeutic efficacy of topically used Luliconazole vs. Terbinafine creams
Mycoses Journal: Published on April 2021Dermatomycoses of zoophilic origin, especially those caused by Trichophyton mentagrophytes, often pose considerable therapeutic problems. This is reflected in the growing number of strains of this species with resistance to terbinafine caused by a mutation in the squalene epoxidase (SQLE) gene. TAKE HOME...
Risk Assessment of Kidney Disease Progression and Efficacy of SGLT2 Inhibition in Patients with Type 2 Diabetes
Diabetes Care Journal (ADA): August, 2023Early identification of patients with type 2 diabetes who are at risk of kidney disease progression is particularly important in the context of new glucose-lowering medications such as sodium-glucose cotransporter 2 (SGLT2) inhibitor (Dapagliflozin, Canagliflozin, Empagliflozin, Ertugliflozin) that can m...