Antiplatelet-anti-fibrinolytichaemostatic-drugs

Aspirin vs Clopidogrel for Chronic Maintenance Monotherapy after PCI: Long-Term Outcomes
AHA Journals (Circulation): Published on November, 2022Once patients have completed their dual antiplatelet therapy, we need to stop one of the medications — which one — ASA or clopidogrel? For many of us, we will keep the ASA and get rid of the other agent like clopidogrel.This study in Korea included 5438 patients who had PCI with drug-elutin...
Association of Intravenous Tranexamic Acid with Thromboembolic Events and Mortality - A Systematic Review
Journal of the American Medical Association (JAMA) SurgeryTranexamic acid is an antifibrinolytic compound which inhibits fibrinolysis by blocking the binding of plasminogen and plasmin to fibrin, thus preventing dissolution of the haemostatic plug. TAKE-HOME MESSAGE Question Is intravenous administration of tranexamic acid associated wi...
Tranexamic Acid for the Prevention of Blood Loss after Cesarean Delivery
The New England Journal of Medicine: Postpartum hemorrhage remains a leading cause of severe maternal complications and death worldwide. Prophylactic administration of an uterotonic agent is recommended to reduce the risk of postpartum hemorrhage. Tranexamic acid has emerged in the past decade as another candidate drug to prevent blood l...
Efficacy of prehospital administration of tranexamic acid in trauma patients
A meta-analysis of the randomized controlled trials: The American Journal of Emergency Medicine Trauma remains a leading cause of death worldwide, and the management of injured patients at risk for hemorrhage has evolved over time. Interventions provided to injured patients during prehospital care, close to the time of injury, result...
The importance of early treatment with Tranexamic acid in bleeding trauma patients
Trauma is the leading cause of death and disability worldwide. In both military and civilian settings, hemorrhage remains the most common cause of preventable death after traumatic injury. In recent years, there has been considerable interest in antifibrinolytic agents for the prevention of hemorrhagic death in severe trauma patients. T...
Tranexamic Acid Reduces Severe Bleeding Risk in Patients Undergoing Noncardiac Surgery
The American College of Cardiology (ACC) & The New England Journal of Medicine (NEJM): Key Prescribing Notes: Perioperative bleeding is common complications in patients undergoing noncardiac surgery, is associated with increased morbidity and mortality. The goal of the POISE-3 trial was to determine whether tranexamic acid, when u...