Cardiovascular-disorders

Annals of Internal Medicine: Published May 2024Testosterone (T) levels slowly decline as we age, and serum hormone-binding globulin (SHBG) levels gradually increase. As SHBG increases, there is less T available to the tissues. There are several conditions that reduce levels of T; these include being overweight, having metabolic dysfunction, liv...
Circulation: Cardiovascular Quality and Outcomes: Published Apr 2024TAKE-HOME MESSAGEThis study used data from the FAST-MI program to examine the effect of lipid-lowering therapy (LLT) (atorvastatin ≥40 mg or equivalent or any combination of a statin and ezetimibe) intensity on long-term mortality in 2258 patients aged 80 years or older who ex...
The Lancet Diabetes & Endocrinology: Published: March, 2024Atherosclerotic cardiovascular disease is a leading cause of death worldwide, and LDL cholesterol is a major causal risk factor.Diabetes substantially increases the risk of atherosclerotic cardiovascular disease.TAKE-HOME MESSAGEIn this participant-level meta-analysis of 19 trials,...
Clinical studies have produced conflicting evidence on the effects of the consumption of tomatoes on blood pressure, and there are limited data from epidemiologic studies. This study assesses whether tomato consumption (Solanum lycopersicum L.) is associated with Systolic (SBP) and Diastolic Blood Pressure (DBP), and the risk of hypertension i...
Circulation: AHA Journals: Published July, 2023Hypertension management remains suboptimal globally, with treatment inertia being identified as one of the main barriers to achieving blood pressure (BP) control. Simpler approaches to achieve target BP levels are needed. TAKE-HOME MESSAGEThe QUARTET study examined the effectiveness of a quadrupl...
American Journal of Obstetrics & Gynecology: Published: April, 2023Hypertensive disorders in pregnancy (HDPs) are major causes of maternal and fetal morbidity and are associated with future maternal risk of cardiovascular disease.Most existing data on hypertensive disorders of pregnancy and short-term cardiovascular disease risks are limited t...
AHA Journals (Circulation): Published on November, 2022Once patients have completed their dual antiplatelet therapy, we need to stop one of the medications — which one — ASA or clopidogrel? For many of us, we will keep the ASA and get rid of the other agent like clopidogrel.This study in Korea included 5438 patients who had PCI with drug-elutin...
The New England Journal of Medicine: Published on December, 2022Hypertension increases the risk of complications and death from cardiovascular disease. Thiazide diuretics are first-line antihypertensive agents that lower blood pressure and prevent adverse cardiovascular outcomes. Early studies suggested that chlorthalidone was superior to hydro...
JAMA Cardiology: Published on April, 2022TAKE-HOME MESSAGEQuestion:  Is low-dose triple combination antihypertensive therapy associated with greater time at target blood pressure compared with usual care?Findings:  This secondary analysis of an open-label randomized controlled clinical trial evaluated whether low-dose triple combination antihyp...
The LANCET: Diabetes & Endocrinology: Published on July, 2022Diabetes is a major cause of death, cardiovascular complications, and health-care burden worldwide.People with type 2 diabetes who have high blood pressure are at an increased risk of morbidity and death from major cardiovascular events.However, there are inadequate randomised contro...
The New England Journal of Medicine (NEJM): Published on April, 2022Antihypertensive treatment during pregnancy reduces the frequency of severe hypertension (blood pressure, ≥160/110 mm Hg) but has not been shown to improve maternal, fetal, or neonatal outcomes and has been associated with an increased risk of small-for-gestational-age birth w...
The 2021 WHO hypertension guideline aims to provide the most current and relevant evidence based global public health guidance on the initiation of treatment (with pharmacological agents) for hypertension in adults. The recommendations target adult, non-pregnant patients who were appropriately diagnosed with hypertension and counseled about li...