Gastrointestinal-hepatic-disorders

ASCRS Guidelines for the Evaluation and Management of Chronic Constipation
The American Society of Colon and Rectal SurgeonsDiseases of the Colon and Rectum: Published October, 2024IntroductionChronic constipation is a prevalent condition that significantly impacts patients' quality of life. The American Society of Colon and Rectal Surgeons (ASCRS) has developed clinical practice guidelines to provide evidence-based re...
Dexlansoprazole and Esomeprazole Do Not Affect Bone Homeostasis in Healthy Postmenopausal Women
Gastroenterology: AGA Journal: Published March, 2019Prior research has shown an association between proton pump inhibitors and fracture risk. This study checked for markers for bone reabsorption and formation and followed bone mineral density and the incidence of fractures. It also looked at levels of calcium, magnesium, phosphorous, and parath...
Dexlansoprazole is Effective in Relieving Heartburn during the Fasting Month of Ramadan
During the holy month of Ramadan, Muslims practice daily fasting from dawn to sunset. This commitment changes their daily food routine in terms of number of meals, quantity of caloric intake, and types of food consumed. This change in consumption patterns during Ramadan has an effect on metabolism and weight, sleeping patterns, and possibly ga...
Comparison of Acid-Lowering Drugs for Endoscopy-Negative Reflux Disease
Neurogastroenterology and Motility Journal: Published: September 2022GERD is a condition that develops when the reflux of stomach contents causes troublesome symptoms and/or complications. These symptoms include typical ones, such as heartburn, regurgitation, or both, angina-mimicking non-cardiac chest pain, and extra-esophageal symptoms,...
Dexlansoprazole for Heartburn Relief
Gastro-esophageal reflux disease (GERD) is a disorder involving troublesome symptoms associated with persistent reflux of gastric contents into the esophagus. Symptoms include heartburn, cough, epigastric pain, vomiting, and regurgitation.GERD is proposed to have 5 distinct presentations—nonerosive GERD (NERD), erosive esophagitis (EE), functio...
Comparative efficacy of Dexlansoprazole vs. esomeprazole in the treatment of Gastro-Esophageal Reflux Disease
Dexlansoprazole is a new proton pump inhibitor (PPI) with a dual delayed-release system. Both dexlansoprazole and esomeprazole are an enantiomer of lansoprazole and omeprazole respectively.TAKE HOME MESSAGEThis study aims to compare the efficacy of Dexlansoprazole with Esomeprazole in healing erosive oesophagitis (EO), the maintenance of healed...
The Effect of Dexlansoprazole on Gastroesophageal Reflux Disease: A Systematic Review and Meta-Analysis
International Journal of Molecular Science: Published on January 2024Gastroesophageal reflux disease (GERD) is a common disease of the digestive system with a worldwide prevalence of 8 to 33% and is characterized by the persistent reflux of gastroduodenal content that ascends through the esophageal tube, causing esophageal and extraesophageal...
Association of Proton Pump Inhibitor Use with the Risk of Kidney Stones
BMJ Open: Published, October, 2023This study aimed to investigate the potential association between PPI use and kidney stones by analysing National Health and Nutrition Examination Survey (NHANES) data from 2007 to 2018. TAKE-HOME MESSAGEThe authors of this large US-based cross-sectional study found that proton-pump inhibitor (PPI) use was asso...
Cumulative PPI Use for More Than 4.4 Years Linked to Increased Risk for Dementia
Neurology: August, 2023Cumulative use of proton pump inhibitors (PPIs) for more than 4.4 years is associated with an increased risk for dementia, according to a study published in Neurology.TAKE-HOME MESSAGEThis study evaluated whether the current and cumulative use of proton pump inhibitors (PPIs) are associated with a higher risk of incident...
Statin Use Reduces Hepatocellular Carcinoma Risk in Patients with NAFLD
Clinical Gastroenterology and Hepatology: February, 2022The incidence rate of hepatocellular carcinoma (HCC) has been increasing for the last 3 decades. Fatty liver progresses from fat accumulation to inflammation to fibrosis to cirrhosis to cancer. Recent evidence suggests potential clinical benefits of statin in cancer chemoprevention a...
Practice Guidance on the Clinical Assessment and Management of Nonalcoholic Fatty Liver Disease (NAFLD)
Lippincott Williams & Wilkins (LWW): Hepatology Journal: Published on May, 2023This new American Association for the Study of Liver Diseases (AASLD) Guidance document reflects many advances in the field pertinent to any practitioner caring for patients with NAFLD and emphasizes advances in noninvasive risk stratification and therapeutics.The mo...
Continuous PPI Use Is Associated With Acute Gastroenteritis during Winter Periods
JAMA Network: November, 2019Proton pump inhibitors (PPIs) are drugs widely prescribed to reduce gastric acidity. Although they are considered globally safe, observational studies have reported significant adverse effects associated with their long-term use, such as osteoporotic-related fractures, vitamin B12 deficiency, kidney disease, or...