Circulation: AHA Journals: Published July, 2023

Hypertension management remains suboptimal globally, with treatment inertia being identified as one of the main barriers to achieving blood pressure (BP) control. Simpler approaches to achieve target BP levels are needed. 

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The QUARTET study examined the effectiveness of a quadruple quarter-dose combination of antihypertensive medications (quadpill) compared with conventional monotherapy for hypertension management.

Among 591 participants, the quadpill resulted in significantly greater reductions in blood pressure measurements across the 24-hour period compared with monotherapy.

At the start of the study, the incidence of uncontrolled blood pressure was 88% and 87% in the monotherapy group and quadpill group, respectively, but this was reduced to 48% and 28%, respectively, at 52 weeks.

QUARTET study (Quadruple Ultra-Low-Dose Treatment for Hypertension) demonstrated that a single-pill combination of 4 BP-lowering medications at ultra-low (quarter) doses is more effective in reducing and maintaining lower unattended office BP than initial monotherapy with uptitration if needed.

This study showed the effectiveness of a quadruple quarter-dose combination of antihypertensive medications for sustained blood pressure control.