Disease-information
Journal of the American Medical
Association (JAMA)
SurgeryTranexamic
acid is an antifibrinolytic compound which inhibits fibrinolysis by blocking
the binding of plasminogen and plasmin to fibrin, thus preventing dissolution
of the haemostatic plug.
TAKE-HOME MESSAGE
Question Is
intravenous administration of tranexamic acid associated wi...
Motor symptoms are those that
affect movement of the body. These are the cardinal symptoms of PD. The main
motor symptoms of PD are tremor, slowness of movement (bradykinesia), stiffness
(rigidity), and poor balance (postural instability). These symptoms are usually
mild in the early stages of the disease. PD patients show additional mo...
The New England Journal of Medicine:
Postpartum
hemorrhage remains a leading cause of severe maternal complications and death worldwide.
Prophylactic administration of an uterotonic agent is recommended to reduce the
risk of postpartum hemorrhage. Tranexamic acid has emerged in the past decade
as another candidate drug to prevent blood l...
A meta-analysis of the randomized
controlled trials: The American
Journal of Emergency Medicine
Trauma remains a leading cause of
death worldwide, and the management of injured patients at risk for hemorrhage
has evolved over time.
Interventions provided to injured
patients during prehospital care, close to the time of injury, result...
NICE guideline:
Suspect
Parkinson's disease in people presenting with tremor, stiffness, slowness,
balance problems and/or gait disorders.
If
Parkinson's disease is suspected, refer people quickly and untreated to a
specialist with expertise in the differential diagnosis of this condition.
Clinical diagnosis
Diagnose
Parkinso...
Introduction
Parkinson’s disease (PD) is a
neurodegenerative disease resulting from progressive death of the dopaminergic
neurons in the brainstem, particularly the substantia nigra pars compacta
(SNc). Besides the hallmark motor symptoms (hypokinesia, rest tremor, rigidity,
and postural instability), PD patients have non-motor symptoms...
Progesterone maintains pregnancy by
enhancing uterine quiescence. During early pregnancy, the syncytiotrophoblast
secretes human chorionic gonadotropin (hCG), which stimulates progesterone
production in the corpus luteum by preventing regression of this tissue.
Low serum hCG or progesterone
levels may predict first trimester abortions....
Treatment guidelines for type 2
diabetes mellitus (T2DM) recommend initiating pharmacotherapy with an oral
antidiabetic drug (OAD) to reduce hyperglycaemia when diet and exercise are
inadequate.
International guidelines recommend
metformin as the first OAD, whereas Japanese guidelines recognize that other
OADs may be more appropriate i...
Metabolic Syndrome and Related
Disorders Journal: Published
Online: 15 Feb 2022
Seborrheic dermatitis (SD) is a
common, chronic inflammatory disease with relapses and remissions.
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This study aimed to evaluate
metabolic syndrome (MS) and glucose metabolism disorders in patients with SD.
The study results showed...
The management of gastroesophageal
reflux disease (GERD) has been revolutionized with the development of proton
pump inhibitors (PPIs). Unfortunately, due to the inherent pharmacokinetic and
pharmacodynamic profiles of conventional PPIs, many patients continue to suffer
from symptoms related to GERD despite appropriate use of PPIs.
Curr...
JAMA: The Journal of the American Medical Association: Published
on April 5, 2022
Epilepsy affects approximately 65
million people worldwide. Persistent seizures are associated with a 20% to 40%
risk of bodily injuries (eg, fractures, burns, concussions) over 12-month
follow-up. The primary goal of epilepsy treatment is to eliminate seiz...
American Diabetes Association (ADA)
Professional Practice Committee: Recommendations
Treatment Strategies
Lifestyle Intervention:
Recommendation
For patients with blood pressure
>120/80 mmHg, lifestyle intervention consists of weight loss when
indicated, a Dietary Approaches to Stop Hypertension (DASH)-style eating
pattern inclu...
