Disease-information

Clinical trials in hypertension have repeatedly shown that adequate blood pressure (BP) control is important for the prevention of cardiovascular morbidity and mortality. However, most patients do not achieve target BP levels, and the majority of them require combination therapy with two or more drugs in order to obtain an adequate BP redu...
American College of Obstetricians and Gynecologists (ACOG): Endometriosis is a chronic, estrogen-dependent condition that causes dysmenorrhea and pelvic pain that affects 6–10% of women of reproductive age. Elagolix is an oral, nonpeptide Gonadotropin-releasing hormone (GnRH) antagonist suppressed estradiol production in a dose-depend...
Tinea unguium (Onychomycosis) is often confused with non-infected nail dystrophy due to skin disease, particularly psoriasis (also, lichen planus). Onychomycosis may look similar to nail dystrophy due to psoriasis but those can be differentiated by presence of psoriasis in the surrounding skin with pitting nail or by circular area of...
American Family Physician (AFP) Journal: Seborrheic dermatitis is a common skin condition in infants, adolescents, and adults. Seborrheic dermatitis is a chronic inflammatory dermatologic condition that usually appears on areas of the body with a large density of sebaceous glands, such as the scalp, face, chest, back, axilla, and gro...
Journal of Fungi: A Systematic Review of Randomized Controlled Trials Tinea pedis, or athlete’s foot, is a superficial fungal infection of the skin of the feet caused by dermatophytes, most commonly Trichophyton rubrum, Trichophyton mentagrophyte and Epidermophyton floccosum. Tinea pedis is common worldwide, with more than 70% of t...
Eosinophilic esophagitis (EoE) is an immune/antigen-mediated, progressive fibrostenotic disease characterized by symptoms of esophageal dysfunction and abnormal eosinophilic infiltration in the esophagus. Despite treatment modalities of dietary antigen elimination or Topical corticosteroids, a subset of patients do not have clinical or histolo...
Gastroesophageal reflux disease (GERD) continues to be among the most common diseases seen by gastroenterologists, surgeons, and primary care physicians. The American College of Gastroenterology (ACG) recently released an updated guideline on diagnosis and management of GERD which was published by the American Journal of Gastroenterology. In t...
The majority (70-93%) of adolescents have discomfort associated with menstruation. Dysmenorrhea is the most common reason for missed school and activities. Up to 20-40% report missed school due to dysmenorrhea, and 40% report a negative effect on school performance and concentration. Adolescents with severe dysmenorrhea have impaired qualit...
Endometriosis affects up to 10% of women of reproductive age, and the main goal of treatment is to relieve symptoms. Progestins have been the mainstay of endometriosis suppression, of which dienogest has become an important option in many parts of the world.   A search of PubMed was conducted for papers published between 2007–2019 o...
Endometriosis is a benign chronic inflammatory estrogen-dependent disease and a well-known cause of infertility. Endometriosis may have a direct harmful effect on fertility not only due to the presence of adhesions and anatomic distortions, but also because of the intrinsic negative impact on oocyte development, embryogenesis, or implantat...
Acute upper gastrointestinal bleeding (AUGIB) is a common medical emergency. In Western countries, its incidence was estimated to be over 100 cases per 100 000 adults per year. Fortunately, the mortality rates of AUGIB have decreased over the past few decades, largely attributable to improvements in endoscopic and pharmacological therapies...
Pathogenesis of adenomyosis involves sex steroid hormone abnormalities, inflammation, fibrosis and neuro angiogenesis, even though the proposed mechanisms are not fully understood. Nowadays, adenomyosis may also be diagnosed by non-invasive techniques, because of imaging advancements.     Adenomyosis often coexists with other gynecologic...