Disease-information

Eosinophilic esophagitis (EoE) is an immune/antigen-mediated, progressive fibrostenotic disease characterized by symptoms of esophageal dysfunction and abnormal eosinophilic infiltration in the esophagus. Despite treatment modalities of dietary antigen elimination or Topical corticosteroids, a subset of patients do not have clinical or histolo...
Gastroesophageal reflux disease (GERD) continues to be among the most common diseases seen by gastroenterologists, surgeons, and primary care physicians. The American College of Gastroenterology (ACG) recently released an updated guideline on diagnosis and management of GERD which was published by the American Journal of Gastroenterology. In t...
The majority (70-93%) of adolescents have discomfort associated with menstruation. Dysmenorrhea is the most common reason for missed school and activities. Up to 20-40% report missed school due to dysmenorrhea, and 40% report a negative effect on school performance and concentration. Adolescents with severe dysmenorrhea have impaired qualit...
Endometriosis affects up to 10% of women of reproductive age, and the main goal of treatment is to relieve symptoms. Progestins have been the mainstay of endometriosis suppression, of which dienogest has become an important option in many parts of the world.   A search of PubMed was conducted for papers published between 2007–2019 o...
Endometriosis is a benign chronic inflammatory estrogen-dependent disease and a well-known cause of infertility. Endometriosis may have a direct harmful effect on fertility not only due to the presence of adhesions and anatomic distortions, but also because of the intrinsic negative impact on oocyte development, embryogenesis, or implantat...
Acute upper gastrointestinal bleeding (AUGIB) is a common medical emergency. In Western countries, its incidence was estimated to be over 100 cases per 100 000 adults per year. Fortunately, the mortality rates of AUGIB have decreased over the past few decades, largely attributable to improvements in endoscopic and pharmacological therapies...
Pathogenesis of adenomyosis involves sex steroid hormone abnormalities, inflammation, fibrosis and neuro angiogenesis, even though the proposed mechanisms are not fully understood. Nowadays, adenomyosis may also be diagnosed by non-invasive techniques, because of imaging advancements.     Adenomyosis often coexists with other gynecologic...
The Pediatric Infectious Disease Journal: Take Home Message: Diarrheal disease is a leading cause of childhood morbidity and mortality globally. Rotavirus is the leading cause of vaccine-preventable diarrhea among children under 5 and is associated with approximately 28% of diarrheal deaths. The highest burden of severe disease and d...
The Pediatric Infectious Disease Journal: Take Home Message: Diarrheal disease is a leading cause of childhood morbidity and mortality globally. Rotavirus is the leading cause of vaccine-preventable diarrhea among children under 5 and is associated with approximately 28% of diarrheal deaths. The highest burden of severe disease and d...
Any type of bleeding during pregnancy can be alarming. About 25% of women experience some bleeding or spotting during their pregnancy. Subchorionic hematomas are the cause of about 20% of all bleeding during the first trimester. This is a type of bleeding that occurs between amniotic membranes. It occurs when the placenta partially detaches...
Any type of bleeding during pregnancy can be alarming. About 25% of women experience some bleeding or spotting during their pregnancy. Subchorionic hematomas are the cause of about 20% of all bleeding during the first trimester. This is a type of bleeding that occurs between amniotic membranes. It occurs when the placenta partially detaches...
PubMed Central: IntroductionThreatened miscarriage is a common disease during early pregnancy, with a morbidity of 30% to 40%, which could develop into a complete miscarriage or dystocia without timely treatment. Many pathogenic factors contribute to the threatened miscarriage, of which lacking progestogens due to the endocrine dysfunction of...