Drugs-for-fungal-infections-anti-fungal

Topical ketoconazole: a systematic review of current dermatological applications and future developments
Ketoconazole is in a class of antifungal medications called imidazoles. It works by inhibiting the growth of fungi that cause the infection. Topical ketoconazole is indicated for the treatment of cutaneous candidosis (including vulvitis), tinea (pityriasis) versicolor and seborrhoeic dermatitis caused by Malassezia (previously called Pi...
Recent advances in therapies for Onychomycosis and its management
PubMed Central: Published June, 2019Onychomycosis is a fungal infection occurring in the nails and may affect the adjacent skin. Typically, it manifests as discoloration of the nail, nail plate thickening, and onycholysis. It is the most common nail pathology and accounts for about 90% of toenail infections worldwide.At present, there are sever...
Is Super Bioavailable Itraconazole better than Conventional Itraconazole?
Due to the changing face of dermatophytosis in India, many dermatologists practice different dosing patterns of itraconazole (ITZ). Recently, a new form of ITZ, super-bioavailable ITZ (SBITZ), has been commercialized to overcome the pharmacokinetic challenges of conventional ITZ (CITZ). ITZ is a weak base lipophilic molecule with a limite...
Combination of Terbinafine twice daily and Itraconazole twice in a pulse dose in resistant Tinea infection
International Journal of Research in Dermatology: March, 2022Tinea caused by trichophyton,    microsporum,    and epidermophyton is the most common fungal infection affecting   20–25%   population globally,   with varying geographic distribution.Due to  Bangladesh’s hot and humid cli...
Effectiveness of Luliconazole for the Treatment of Tinea Infections
The prevalence of superficial fungal infections across the globe is increasing from 20-25%. Superficial infections are mostly caused by dermatophytes. Depending on the site affected, the dermatophytes are clinically classified as Tinea capitis (head), Tinea faciei (face), Tinea barbae (beard), Tinea manus (hand), Tinea corporis (body), Tinea c...
Oral Medications to Treat Toenail Fungal Infection
JAMA: The Journal of the American Medical AssociationThe authors investigated different oral antifungal medications used to treat toenail fungal infections.TAKE-HOME MESSAGECompared with placebo, high-quality evidence supports better clinical (ie, normal appearance of the toenail) and mycological (negative culture, microscopy, or both) results...
The unprecedented epidemic-like scenario of Dermatophytosis: Antifungal resistance and treatment options
There has been a significant increase in the incidence of chronic, relapsing, recurrent cases of superficial dermatophytosis in India that are also often unresponsive to conventional drugs and doses of recommended antifungal treatment. Almost 15– 20% of the outpatient department cases are those of chronic dermatophytosis. Recurrences and relaps...
Therapeutic efficacy of topically used Luliconazole vs. Terbinafine creams
Mycoses Journal: Published on April 2021Dermatomycoses of zoophilic origin, especially those caused by Trichophyton mentagrophytes, often pose considerable therapeutic problems. This is reflected in the growing number of strains of this species with resistance to terbinafine caused by a mutation in the squalene epoxidase (SQLE) gene. TAKE HOME...
Tinea versicolor: an updated review
PubMed Central: November, 2022Tinea versicolor is a common superficial fungal infection of the skin with various clinical manifestations. This review aims to familiarize physicians with the clinical features, diagnosis and management of tinea versicolor.Tinea versicolor is caused by Malassezia species, notably M. globosa, M....
Once-daily topical luliconazole for the treatment of superficial fungal infections
Infection and Drug Resistance Journal:Tinea is superficial fungal infections typically caused by dermatophytes.Superficial fungal infections are widespread, with an estimated worldwide prevalence of 20%–25%, and include tinea pedis (athlete’s foot), tinea cruris (jock itch), and tinea corporis (ringworm), among othersTopical allylamine (terbinaf...
Efficacy of oral Terbinafine vs Itraconazole in treatment of dermatophytic infection of skin
Indian Journal of Pharmacology: Published: May, 2019Dermatophytic infections are the common fungal infections aggravated by hot and humid climate. Terbinafine and Itraconazole are commonly used oral antifungal agents for the same. However, resistance to these drugs is being seen increasingly when used in the conventional doses and duration. In...
Management of tinea corporis, tinea cruris, and tinea pedis: A comprehensive review
Principles of TherapyTopical AntifungalsTopical medications have better pharmacokinetics than their systemic counterparts. Hence, the combination is expected to have better mycological clearance than systemic and topical alone. The combination should be from different groups for wide coverage and also to prevent the emergence of resistance. Dru...