Drug-information

Topical ketoconazole: a systematic review of current dermatological applications and future developments
Ketoconazole is in a class of antifungal medications called imidazoles. It works by inhibiting the growth of fungi that cause the infection. Topical ketoconazole is indicated for the treatment of cutaneous candidosis (including vulvitis), tinea (pityriasis) versicolor and seborrhoeic dermatitis caused by Malassezia (previously called Pi...
Evaluating Primary Treatment Outcomes in Individuals Presenting With Advanced Glaucoma
Ophthalmology: The American Academy of Ophthalmology: Published: January, 2024Sight loss from glaucoma is often preventable with early diagnosis and treatment. Reducing IOP is the only proven effective treatment for glaucoma. Better IOP control at an early stage reduces the risk of further progression. Primary treatment options for advanced gl...
Recent advances in therapies for Onychomycosis and its management
PubMed Central: Published June, 2019Onychomycosis is a fungal infection occurring in the nails and may affect the adjacent skin. Typically, it manifests as discoloration of the nail, nail plate thickening, and onycholysis. It is the most common nail pathology and accounts for about 90% of toenail infections worldwide.At present, there are sever...
Is Super Bioavailable Itraconazole better than Conventional Itraconazole?
Due to the changing face of dermatophytosis in India, many dermatologists practice different dosing patterns of itraconazole (ITZ). Recently, a new form of ITZ, super-bioavailable ITZ (SBITZ), has been commercialized to overcome the pharmacokinetic challenges of conventional ITZ (CITZ). ITZ is a weak base lipophilic molecule with a limite...
Combination of Terbinafine twice daily and Itraconazole twice in a pulse dose in resistant Tinea infection
International Journal of Research in Dermatology: March, 2022Tinea caused by trichophyton,    microsporum,    and epidermophyton is the most common fungal infection affecting   20–25%   population globally,   with varying geographic distribution.Due to  Bangladesh’s hot and humid cli...
Outcomes of Using Cefepime vs Piperacillin–Tazobactam in Adults Hospitalized with Acute Infection
JAMA: The Journal of the American Medical Association: October, 2023Cefepime and piperacillin-tazobactam are commonly administered to hospitalized adults for empirical treatment of infection. Although piperacillin-tazobactam has been hypothesized to cause acute kidney injury and cefepime has been hypothesized to cause neurological dysfunction,...
Effectiveness of Luliconazole for the Treatment of Tinea Infections
The prevalence of superficial fungal infections across the globe is increasing from 20-25%. Superficial infections are mostly caused by dermatophytes. Depending on the site affected, the dermatophytes are clinically classified as Tinea capitis (head), Tinea faciei (face), Tinea barbae (beard), Tinea manus (hand), Tinea corporis (body), Tinea c...
Effect of Initial Treatment with Quadpill vs Standard Dose Monotherapy in Patients with Hypertension
Circulation: AHA Journals: Published July, 2023Hypertension management remains suboptimal globally, with treatment inertia being identified as one of the main barriers to achieving blood pressure (BP) control. Simpler approaches to achieve target BP levels are needed. TAKE-HOME MESSAGEThe QUARTET study examined the effectiveness of a quadrupl...
Oral Medications to Treat Toenail Fungal Infection
JAMA: The Journal of the American Medical AssociationThe authors investigated different oral antifungal medications used to treat toenail fungal infections.TAKE-HOME MESSAGECompared with placebo, high-quality evidence supports better clinical (ie, normal appearance of the toenail) and mycological (negative culture, microscopy, or both) results...
The unprecedented epidemic-like scenario of Dermatophytosis: Antifungal resistance and treatment options
There has been a significant increase in the incidence of chronic, relapsing, recurrent cases of superficial dermatophytosis in India that are also often unresponsive to conventional drugs and doses of recommended antifungal treatment. Almost 15– 20% of the outpatient department cases are those of chronic dermatophytosis. Recurrences and relaps...
Elevated Risk of Developing Type 2 Diabetes in People with Psychiatric Disorders
Journal of Diabetes and its Complications: August 2023Nearly one out of three individuals will develop a psychiatric disorder during their life. Severe psychiatric disorders are associated with higher mortality rates, with 10–20 life-years lost compared to individuals without a severe psychiatric disorderSeveral psychiatric disorders are li...
Therapeutic efficacy of topically used Luliconazole vs. Terbinafine creams
Mycoses Journal: Published on April 2021Dermatomycoses of zoophilic origin, especially those caused by Trichophyton mentagrophytes, often pose considerable therapeutic problems. This is reflected in the growing number of strains of this species with resistance to terbinafine caused by a mutation in the squalene epoxidase (SQLE) gene. TAKE HOME...