Drug-information
Trauma is the leading cause of
death and disability worldwide. In both military and civilian settings, hemorrhage
remains the most common cause of preventable death after traumatic injury. In
recent years, there has been considerable interest in antifibrinolytic agents
for the prevention of hemorrhagic death in severe trauma patients.
T...
Annals of Internal Medicine:
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In this UK Biobank study, the
authors sought to evaluate the correlation between serum testosterone levels
and cardiac events, finding no association between total testosterone and risk
for major adverse cardiovascular events (MACE).
Men with lower total testosterone
concentrations wer...
The American College of Cardiology (ACC) & The New England Journal of
Medicine (NEJM):
Key Prescribing Notes:
Perioperative bleeding is common
complications in patients undergoing noncardiac surgery, is associated with
increased morbidity and mortality.
The goal of the POISE-3 trial was
to determine whether tranexamic acid, when u...
Overview of OsteoporosisOsteoporosis is a disease
characterized by low bone mass and deterioration of bone tissue and bone
structure, which can lead to increased bone fragility and risk of fracture. The most common fractures associated
with osteoporosis are in the hip, spine, wrist, and shoulder.
Osteoporosis is the major cause
o...
The Lancet:
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It is well-established that blood pressure control is an
important strategy in reducing cardiovascular events among people with
diabetes.
This data analysis that included studies comprised of over
145,000 participants finds that a reduction of 5 mm Hg in systolic blood
pressure was associated with an...
High
blood pressure is the leading cause of mortality and cardiovascular disease
globally, and most of the disease burden occurs in low- and middle-income
countries. Recent guidelines recommend lower blood pressure targets
among high-risk patients, increasing the need for more effective treatment
strategies.Treatment with a pill combining low...
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The
authors investigated physician adherence with recommending peptic ulcer
disease (PUD) prophylaxis for elderly patients who were receiving dual
antiplatelet therapy or anticoagulation or who were at risk of bleeding
PUD, as per expert consensus guidelines from the American College of
Gastroenterol...
Peptic ulcer disease is often defined as a mucosal break
greater than 3-5 mm in the stomach or duodenum with a visible depth. It is
therefore an endoscopic diagnosis in contrast to dyspepsia, which is a clinical
diagnosis based on symptoms alone. Peptic ulcer disease results from an
imbalance between factors that protect the mucosa of the stoma...
Antacids neutralize gastric acid
and are, broadly used in the
treatment of gastroesophageal reflux disease (GERD) in adults. They are
utilized for more than 2,000 years, though evidence of the effectiveness and
safety is limited in infants [1]. Antacids have an effect on the short-term
relief of heartburn and the healing of esophagitis. Charac...
The rapidly escalating coronavirus
disease 2019 (COVID-19) pandemic has focused attention on the diagnosis and
treatment of patients with acute respiratory infection in an unprecedented
manner. Although most of the lung injury patients have is believed to be caused
by the virus, concern over bacterial co-infection also informs current
treatmen...
Migraine as a primary headache
disorder with substantial pain is included in the 20 most disabling diseases
according to the World Health Organization.Lifestyle management, acute
treatment, and preventive treatment are three approaches to treat migraine.
Prophylactic therapy for migraine is recommended in patients with four or more
attacks per...
Gastrointestinal (GI) bleeding is
the most common GI diagnosis necessitating. Upper GI bleeding (UGIB) refers to
bleeding originating from sites in the esophagus, stomach, or duodenum.AbstractThe American Journal of
Gastroenterology society performed systematic reviews addressing predefined
clinical questions to develop recommendations with the...
