Drug-information
Proton
pump inhibitors (PPIs) are among the most commonly used medications in the
world. Developed for the treatment and prevention of acid-mediated upper
gastrointestinal conditions, these agents are being used increasingly for
indications where their benefits are less certain.
PPI over prescription
imposes an economic cost and contri...
JAMA Network
Anemia is
the most widespread nutritional deficiency among pregnant females in the world.
A total of 40.05% of pregnant females worldwide had anemia during pregnancy,
with the highest prevalence (48.15%) in Southeast Asia. Because of
the high prevalence of anemia, any adverse maternal and fetal outcomes
associated with...
JAMA Network
From 2016 to 2020, increases were
seen in anxiety and depression among children, while decreases were observed in
parent or caregiver mental health and coping with parenting demands, according
to a study published in JAMA
Pediatrics.
The recent release of the 2020
National Survey of Children’s Health (NSCH) offers an opp...
The American Journal of Gastroenterology
TAKE-HOME MESSAGE
This nested case-control study
examined adults with gastric, liver, colorectal, and pancreatic cancers and use
of PPI for ≥2 years. Cancer risks for PPI dose and duration were also
evaluated.
While exploratory analysis found
an increased cancer risk for PPI use ≥10 years,...
Journal of Oral and Maxillofacial Surgery:
Odontogenic infections are a common
problem in dentistry, and their treatment often requires the use of antibiotics
besides the removal of the source of infection, which frequently makes it more
difficult for clinicians to make a decision regarding the choice of antibiotic.
The pathogenesis...
Key Information
In the last decade, gastro-esophageal
reflux disease (GERD) and its complications of Barrett's oesophagus and
oesophageal adenocarcinoma are increasingly prevalent, especially in Asia. The
rise in GERD among Asians is largely attributed to a recent increase in the
prevalence of obesity.
Physiological dysfunction of the...
JAMA Network: A Systematic Review
and Meta-analysis
Osteoporosis is characterized by
reduced bone mass and fragmentation of bone architecture, resulting in an
increased risk of fracture. Approximately 1 in 2 women and 1 in 5 men aged 50
years or older will experience an osteoporotic fracture in their remaining lifetime.
Hip fracture is...
JAMA Surgery:
Surgical
site infections (SSIs) are infections of the incision or organ or space that
occur after surgery. Surgical patients initially seen with more
complex comorbidities and the emergence of antimicrobial-resistant pathogens
increase the cost and challenge of treating SSIs. The prevention of SSI is
increasingly important...
Osteoporosis is a bone disorder
that increases a person’s risk of fracture due to low bone mineral density
(BMD), impaired bone microarchitecture/mineralization, and/or decreased bone
strength. Osteoporotic fractures most commonly occur at the hip, spine and
wrist.
Fracture prevalence increases
dramatically with age. The majority of pos...
BioMed Central (BMC) Gastroenterology Journal:
Gastroesophageal
reflux disease (GERD) is one the most common medical complaints in
pregnant women. Its prevalence has been reported to reach as high as 80% in
certain populations. The prevalence of GERD is also increased as pregnancy
progresses from the first to third trimester. Some women...
The New England Journal of Medicine (NEJM):
Obesity is a major global public
health challenge. Weight loss by means of lifestyle modification has been
documented to be the cornerstone of weight management. Daily calorie
restriction is a well-established primary weight-loss strategy for obese
patients.
However, most trials of dietary...
The New England Journal of Medicine
(NEJM):
Locally
advanced rectal cancer is typically managed with multimodal therapy, including
chemotherapy, radiation, and surgery.
Owing to
the complications of surgery and the high frequency of pathological complete
response, interest in organ-sparing nonoperative management is increasing....
