Drug-information
JAMA Network: Published on June, 2022Montelukast, the most widely used
leukotriene-modifying agent (LTMA), is a selective leukotriene receptor
antagonist and is currently indicated for prophylactic and chronic treatment of
asthma, relief of symptoms of allergic rhinitis, and acute prevention of
exercise-induced bronchoconstriction.This propensi...
ACP Journals: Annals of Internal Medicine: Published on
November, 2022Current guidelines recommend using
direct oral anticoagulants (DOACs) over warfarin in patients with atrial
fibrillation (AF), but head-to-head trial data do not exist to guide the choice
of DOAC.The aim
of the study is to do a large-scale comparison between all DOACs
(apix...
Lung Function & the Risk of Exacerbation in Patients with COPD Treated With the β-Blocker Metoprolol
Annals of the American Thoracic Society: Published on October, 2022Chronic obstructive pulmonary disease (COPD) is a leading
cause of death worldwide [1, 2]. COPD exacerbations that are related to poor
prognosis and severe COPD exacerbations requiring hospital admission.Beta-adrenoceptor (β-ADR) antagonists, or “beta blockers,”
are indicated for...
Coronavirus disease 2019 (COVID-19)
is one of the most significant pandemics in human history caused by the virus
known as severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2).
SARS-CoV-2 has infected >530 million people, of which >6.3 million have
died since June 23, 2022. Recent research has indicated that
COVID-19 might be a risk fa...
The Lancet: Published on October, 2022Hypertension, or high blood
pressure, is a key risk factor for cardiovascular disease worldwide. Previous clinical trials supporting
the cardiovascular benefits of antihypertensive therapy primarily use
conventional morning dosing. Additionally, cardiovascular events
are temporally associated with the morni...
European Heart Journal: September, 2022Cardiovascular (CV) disease (CVD) is the leading cause of
morbidity and mortality worldwide, despite continuous improvement of medical
treatment, diagnosis, and risk factor control. It has been clearly
demonstrated that statin therapy confers significant mortality and morbidity
benefits in both the primary...
The Lancet: Published on September, 2022A
promising malaria vaccine was up to 80% effective at preventing the disease in
young children who received a booster shot at one year following a primary
three-dose regime maintained high efficacy against malaria, and continued to
meet the World Health Organization’s Malaria Vaccine Technology Roadmap g...
JAMA Cardiology: Published on November, 2022TAKE-HOME MESSAGEQuestion: Does vitamin D prevent statin-associated muscle
symptoms and reduce statin discontinuation?This study assessed whether vitamin D supplementation (2000
IU of cholecalciferol) would prevent statin-associated muscle symptoms (SAMS)
and reduce statin discontinuation in 2083 part...
JAMA Cardiology: Published on November, 2022TAKE-HOME MESSAGEQuestion: Does vitamin D prevent statin-associated muscle
symptoms and reduce statin discontinuation?This study assessed whether vitamin D supplementation (2000
IU of cholecalciferol) would prevent statin-associated muscle symptoms (SAMS)
and reduce statin discontinuation in 2083 part...
Journal of the American College of Cardiology: Published on December,
2022Healthy dietary patterns are rich
in micronutrients, but their influence on cardiovascular disease (CVD) risks
has not been systematically quantified.The goal of this study was to
provide a comprehensive and most up-to-date evidence-based map that
systematically quantifi...
ACP Journals: Annals of Internal Medicine: Published
on February 2023In this systematic review and
meta-analysis, the authors assessed whether vitamin D administration decreases
the risk for diabetes in individuals with prediabetes. TAKE-HOME MESSAGECombining data from three
randomized trials, the authors demonstrated that vitamin D reduced the...
PubMed Central: Published on January, 2021Subchorionic hematoma (SCH) refers
to a collection of blood between the chorionic membrane and the uterine wall as
caused by the separation of the chorion from the endometrium. It is the most
common sonographic abnormality in pregnant women with symptoms of threatened
miscarriage and the most common cau...
