Drug-information

Effect of a combination of Telmisartan and Amlodipine on patients with Hypertension
Hypertension is considered a major health problem around the world. It’s associated with increasing risk of mortality due to its complication which has a great impact on patient’s life quality. Chronic uncontrolled hypertension is a significant risk factor for cardiovascular mortality and morbidity, strokes, heart failure, and renal fai...
Type 2 Diabetes Mellitus: Outpatient Insulin Management
In patients with type 2 diabetes mellitus, insulin may be used to augment therapy with oral glycemic medications or as insulin replacement therapy.The goals of therapy should be individualized based on many factors, including age, life expectancy, comorbid conditions, duration of diabetes, risk of hypoglycemia, cost, patient motivation, and qu...
Guideline for Treatment of Prolonged Seizures in Children and Adults
American Epilepsy Society issues guideline and treatment algorithm for convulsive status epilepticus. The guideline was endorsed by the Epilepsy Foundation, Child Neurology Society, and American College of Emergency Physicians.Status epilepticus – continuous or rapid sequential seizure activity for 30 minutes or more – is a medical emergency wi...
Alginate Therapy Is Effective Treatment for Reflux Symptoms
TAKE-HOME MESSAGE The authors of this meta-analysis evaluated the efficacy of alginate-containing compounds for the treatment of gastroesophageal reflux disease (GERD) symptoms. The odds of resolution of GERD symptoms was significantly greater with alginate-based therapies than with placebo or antacids. Alginate therap...
Long-Term Treatment of Bipolar Disorder with Valproate
Updated Systematic Review and Meta-analyses:Bipolar disorder (formerly called manic depression) is a mood disorder characterized by periods of depression and periods of abnormally-elevated mood.Valproate is an anticonvulsant drug that is frequently used in maintenance treatment of bipolar disorder. Clinicians and patients should consider accept...
Statin Therapy May Lead to Diabetes Progression
JAMA Internal MedicineTAKE-HOME MESSAGEThis retrospective study evaluated the association between statin initiation and diabetes progression. Progression of diabetes occurred in significantly more statin users. There was a dose–response relationship with higher-intensity statin use.The study examined 12 years of data on patients covered by the...
Diagnosis and Management of Generalized Anxiety Disorder in Adults
Generalized anxiety disorder (GAD) is the most common mental disorders. The hallmark of GAD is excessive, out-of-control worry. This condition can negatively impact a patient's quality of life and disrupt important activities of daily living. Women are twice as likely as men to have the disorder. It often begins in childhood or adolescence...
Association of Intravenous Tranexamic Acid with Thromboembolic Events and Mortality - A Systematic Review
Journal of the American Medical Association (JAMA) SurgeryTranexamic acid is an antifibrinolytic compound which inhibits fibrinolysis by blocking the binding of plasminogen and plasmin to fibrin, thus preventing dissolution of the haemostatic plug. TAKE-HOME MESSAGE Question Is intravenous administration of tranexamic acid associated wi...
Tranexamic Acid for the Prevention of Blood Loss after Cesarean Delivery
The New England Journal of Medicine: Postpartum hemorrhage remains a leading cause of severe maternal complications and death worldwide. Prophylactic administration of an uterotonic agent is recommended to reduce the risk of postpartum hemorrhage. Tranexamic acid has emerged in the past decade as another candidate drug to prevent blood l...
Efficacy of prehospital administration of tranexamic acid in trauma patients
A meta-analysis of the randomized controlled trials: The American Journal of Emergency Medicine Trauma remains a leading cause of death worldwide, and the management of injured patients at risk for hemorrhage has evolved over time. Interventions provided to injured patients during prehospital care, close to the time of injury, result...
Glycaemic efficacy and safety profile of Empagliflozin as add-on to linagliptin in a fixed-dose combination in type 2 diabetes
Treatment guidelines for type 2 diabetes mellitus (T2DM) recommend initiating pharmacotherapy with an oral antidiabetic drug (OAD) to reduce hyperglycaemia when diet and exercise are inadequate. International guidelines recommend metformin as the first OAD, whereas Japanese guidelines recognize that other OADs may be more appropriate i...
Managing Gastroesophageal Reflux Disease (GERD)-comparative efficacy and outcomes of Dexlansoprazole MR
The management of gastroesophageal reflux disease (GERD) has been revolutionized with the development of proton pump inhibitors (PPIs). Unfortunately, due to the inherent pharmacokinetic and pharmacodynamic profiles of conventional PPIs, many patients continue to suffer from symptoms related to GERD despite appropriate use of PPIs. Curr...