Antacids neutralize gastric acid
and are, broadly used in the
treatment of gastroesophageal reflux disease (GERD) in adults. They are
utilized for more than 2,000 years, though evidence of the effectiveness and
safety is limited in infants [1]. Antacids have an effect on the short-term
relief of heartburn and the healing of esophagitis. Characteristic antacids
consist of alkali complexes of aluminum and/or magnesium, aluminum and
magnesium phosphates, magnesium trisilicate, carbonate, and bicarbonate salts
[2].
Alginate-based raft-forming
formulations vary from conventional antacids by forming a gel on the surface of
the gastric contents and contain sodium or potassium bicarbonate.
Alginates and antacids components are frequently combined in one product. Because of potential toxicity, prolonged use of antacids should be avoided [3].
1. Mandel KG,
Daggy BP, Brodie DA, Jacoby HI. Review article: alginate-raft formulations in
the treatment of heartburn and acid reflux. Aliment Pharmacol Ther. 2000;
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Faure C. Drug therapy; acid-peptic disease. In: Walker W, Goulet O, Kleinman
RE, Sherman PM, Shneider BL, Sanderson IR, editors. Pediatric gastrointestinal
disease. Ontario: BC Decker; 2004. p. 2086–7.Google Scholar
3. Vandenplas
Y, Rudolph CD, Di Lorenzo C, et al. North American Society for Pediatric
Gastroenterology Hepatology and Nutrition, European Society for Pediatric
Gastroenterology Hepatology and Nutrition. Pediatric gastroesophageal reflux
clinical practice guidelines: joint recommendations of the North American
society of pediatric gastroenterology, hepatology, and nutrition and the
European society of pediatric gastroenterology, hepatology, and nutrition. J
Pediatr Gastroenterol Nutr. 2009; 49:498–547.
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