Gastrointestinal-hepatic-disorders

Proton pump inhibitors and risk of colorectal cancer
British Medical Journals (BMJ): IntroductionProton pump inhibitors (PPIs) are commonly prescribed drugs indicated for several gastric conditions, including peptic ulcer disease, GERD and Barrett’s oesophagus. Recent evidence suggests that PPIs are commonly overprescribed, either in patients without an evidence-based indication fo...
Does PPI Use increase the Risk of Gastric, Colorectal, Liver, and Pancreatic Cancers?
The American Journal of Gastroenterology TAKE-HOME MESSAGE This nested case-control study examined adults with gastric, liver, colorectal, and pancreatic cancers and use of PPI for ≥2 years. Cancer risks for PPI dose and duration were also evaluated. While exploratory analysis found an increased cancer risk for PPI use ≥10 years,...
Risk Factors for Community-associated Clostridium difficile-associated Diarrhea in Children
The Pediatric Infectious Disease Journal: Clostridium difficile is an important cause of antibiotic-associated diarrhea and the most widely recognized diarrheal pathogen acquired in healthcare settings. Antibiotic or gastric acid suppressant exposure, gastrointestinal feeding devices, and certain medical conditions, such as malign...
Proton pump inhibitors (PPI) Does Not Affect Bone Homeostasis in Healthy Postmenopausal Women
Proton pump inhibitors (PPIs) have been widely used for decades to treat acid-related diseases. PPIs exhibit a well-established safety profile and reduce gastric acid more effectively than histamine-2 receptor antagonists or antacids. However, observational studies suggest that long-term PPI therapy is associated with osteoporotic fract...
The effectiveness of alginate-antacids vs non-alginate antacid in suppression of acid pocket & post-prandial reflux in obese individuals
Key Information In the last decade, gastro-esophageal reflux disease (GERD) and its complications of Barrett's oesophagus and oesophageal adenocarcinoma are increasingly prevalent, especially in Asia. The rise in GERD among Asians is largely attributed to a recent increase in the prevalence of obesity. Physiological dysfunction of the...
Efficacy and safety of alginate-antacids for relieving Heartburn during Pregnancy & Lactation
BioMed Central (BMC) Gastroenterology Journal: Gastroesophageal reflux disease (GERD) is one the most common medical complaints in pregnant women. Its prevalence has been reported to reach as high as 80% in certain populations. The prevalence of GERD is also increased as pregnancy progresses from the first to third trimester. Some women...
A pharmacovigilance study of association between PPI and Dementia event based on FDA adverse event reporting system data
Proton pump inhibitor (PPI) was commonly used worldwide, to treat peptic ulcer disease (PUD), gastroesophageal reflux disease (GERD), Helicobacter pylori infection, or prevent side effects of glucocorticoids or non-steroidal anti-inflammatory drugs (NSAIDs). However, PPI agents were also overused by off label indication, excessive dosage an...
Association between Proton Pump Inhibitor use and risk of Cardiovascular Disease
The American Journal of Gastroenterology: Proton pump inhibitors (PPIs) are a class of effective medications used to treat various acid-related disorders. Their use in the clinical setting has increased rapidly and tremendously. PPIs are among the most commonly used medications worldwide. However, the widespread availability of these...
Guidelines on the Management of Eosinophilic Oesophagitis in Children and Adults
The British Medical Journal (BMJ): British Society of Gastroenterology (BSG) and British Society of Paediatric Gastroenterology, Hepatology and Nutrition (BSPGHAN) joint consensus guidelineThese joint consensus guidelines from the British adult and paediatric gastroenterology societies utilize the GRADE methodology to make recommendatio...
Guidelines on the Diagnosis of Eosinophilic Oesophagitis in Children and Adults
The British Medical Journal (BMJ): British Society of Gastroenterology (BSG) and British Society of Paediatric Gastroenterology, Hepatology and Nutrition (BSPGHAN) joint consensus guidelines Eosinophilic oesophagitis is a condition characterised by symptoms of dysphagia and/or food impaction in adults, and feeding problems, abdominal...
Antacid & Alginate is more effective than antacid in controlling post-prandial oesophageal acid exposure in GERD patients
Heartburn is a cardinal symptom of gastro-oesophageal reflux disease (GERD) and is among the most common patient complaints encountered by physicians. TAKE HOME MESSAGE: This study compared the effect of Antacid & Alginate Liquid to an antacid in controlling post-prandial acid reflux in GERD patients. The current investigation demons...
An update on drug-drug interactions associated with proton pump inhibitors
Expert Opinion on Drug Metabolism & Toxicology Journal: Published on: 11 Jul 2022 Proton pump inhibitors (PPIs) are widely prescribed for the treatment of gastric acid-related disorders and the eradication of Helicobacter pylori. In addition, they are routinely prescribed for the prevention of gastrointestinal bleeding in patients receiv...