Covid-19

A new and highly transmissible BF.7 strain of the Omicron variant has been found to be behind a wider surge of COVID infections in China and is spreading rapidly around the world. It has been found in the United States, Denmark, Germany, France, and India. The highly contagious new Omicron sub-variant of coronavirus, BF.7, has been detected in...
The LANCET: Published on December, 2022Oral antivirals have been an important addition to efforts to minimise adverse COVID-19 outcomes in individuals at high risk.The earlier first trial of molnupiravir showed only a 30% reduction of hospitalisations and deaths with molnupiravir compared with placebo. Subsequent observational studies in...
The New England Journal of MedicineMolnupiravir is an orally administered form of a potent ribonucleoside analog that inhibits the replication of SARS-CoV-2. For nonhospitalized, unvaccinated adults with mild-to-moderate COVID-19 and at least one risk factor for severe disease, molnupiravir reduces the risk for hospitalization or death, accordi...
The U.S. Food and Drug Administration approved the emergency use of the molnupiravir pill for the treatment of mild-to-moderate coronavirus disease 2019 in nonhospitalized adult patients with positive results of direct SARS-CoV-2 viral testing who are at high risk for progressing to severe COVID-19, including hospitalization or death.Does molnu...
NICE guidelines:Take Home MessagesDo not offer an antibiotic for preventing or treating Pneumonia if SARS-CoV-2, another virus, or a fungal infection is likely to be the cause.Evidence as of March 2021 suggests that bacterial co-infection occurs in less than about 8% of people with COVID-19, and could be as low as 0.1% in people in hospital wit...
Omicron driving spike in new Covid-19 cases in Bangladesh recently and expected to rise in coming days according to health officials. The Covid-19 positivity rate in Bangladesh has reached the highest-ever 33.37% in last week. The health authorities recorded 15,440 new infections after testing 46,268 samples across the country. The latest figure...
The National Institute for Health and Care Excellence (NICE) GuidanceManaging cough Recommendations·       Encourage patient with cough to avoid lying on their backs, if possible, because this may make coughing less effective.·       Be aware that older people or those with comorbidities, frailty, impaired immunity or a reduced ability to cough...
Nirmatrelvir and Ritonavir is the first oral agent authorized by FDA (Emergency Use Authorization) for treatment of mild-to-moderate coronavirus disease in adults and pediatric patients.  In a randomized, double-blind, placebo-controlled clinical trial, Nirmatrelvir and Ritonavir significantly reduced the proportion of people with COVI...
NICE guidelines:Antibiotic treatment in the communityRecommendationsDo not offer an antibiotic for preventing secondary bacterial pneumonia in people with COVID 19. If a person has suspected or confirmed secondary bacterial pneumonia, start antibiotic treatment as soon as possible. Advise people to seek medical help without delay if their sympt...
The U.S. Food and Drug Administration (USFDA) issued an emergency use authorization (EUA) for a new monoclonal antibody for the treatment of COVID-19 that retains activity against the omicron variant. The EUA for Bebtelovimab is for the treatment of mild to moderate COVID-19 in adults and pediatric patients (12 years of age and older we...
The COVID-19 Treatment Guidelines: On December 22 and 23, 2021, the Food and Drug Administration (FDA) issued Emergency Use Authorizations (EUAs) that allow 2 new oral antiviral agents to be used in this patient population: ritonavir-boosted nirmatrelvir and molnupiravir. Ritonavir-Boosted Nirmatrelvir Nirmatrelvir is an orally bi...
Journal of Neuro-Ophthalmology: TAKE-HOME MESSAGE This study reviewed published literature regarding the ophthalmic manifestations of COVID-19. Findings revealed that eye pain was caused by conjunctivitis, episcleritis, scleritis, and optic neuritis, and headache was the result of trigeminal nerve invasion and vascular effects. These mani...