Covid-19
A new and highly transmissible BF.7 strain of the Omicron
variant has been found to be behind a wider surge of COVID infections in China
and is spreading rapidly around the
world. It has been found in the United States, Denmark, Germany,
France, and India. The highly contagious
new Omicron sub-variant of coronavirus, BF.7, has been detected in...
The LANCET: Published on
December, 2022Oral
antivirals have been an important addition to efforts to minimise adverse
COVID-19 outcomes in individuals at high risk.The earlier first
trial of molnupiravir showed only a 30% reduction of hospitalisations and
deaths with molnupiravir compared with placebo. Subsequent observational
studies in...
The New England Journal of MedicineMolnupiravir is an orally
administered form of a potent ribonucleoside analog that inhibits the
replication of SARS-CoV-2. For nonhospitalized, unvaccinated adults with
mild-to-moderate COVID-19 and at least one risk factor for severe disease,
molnupiravir reduces the risk for hospitalization or death, accordi...
The U.S. Food and Drug
Administration approved the emergency use of the molnupiravir pill for the
treatment of mild-to-moderate coronavirus disease 2019 in nonhospitalized adult patients with positive
results of direct SARS-CoV-2 viral testing who are at high risk for progressing
to severe COVID-19, including hospitalization or death.Does molnu...
NICE guidelines:Take Home MessagesDo not offer an antibiotic
for preventing or treating Pneumonia if SARS-CoV-2, another virus, or a fungal
infection is likely to be the cause.Evidence as of March 2021
suggests that bacterial co-infection occurs in less than about 8% of people
with COVID-19, and could be as low as 0.1% in people in hospital wit...
Omicron driving spike in new Covid-19 cases in Bangladesh
recently and expected to rise in coming days according to health officials. The Covid-19 positivity rate in Bangladesh has reached the
highest-ever 33.37% in last week. The health authorities recorded 15,440 new infections after
testing 46,268 samples across the country. The latest figure...
The National Institute for Health and Care Excellence (NICE) GuidanceManaging cough Recommendations· Encourage patient
with cough to avoid lying on their backs, if possible, because this may make
coughing less effective.· Be aware
that older people or those with comorbidities, frailty, impaired immunity or a
reduced ability to cough...
Nirmatrelvir and Ritonavir is the
first oral agent authorized by FDA (Emergency Use Authorization) for treatment
of mild-to-moderate coronavirus disease in adults and
pediatric patients.
In a randomized, double-blind,
placebo-controlled clinical trial, Nirmatrelvir and Ritonavir significantly
reduced the proportion of people with COVI...
NICE guidelines:Antibiotic treatment in the communityRecommendationsDo not offer an antibiotic for
preventing secondary bacterial pneumonia in people with COVID 19. If a person has suspected or
confirmed secondary bacterial pneumonia, start antibiotic treatment as soon as
possible. Advise people to seek medical help
without delay if their sympt...
The U.S. Food and Drug
Administration (USFDA) issued an emergency use authorization (EUA) for a new
monoclonal antibody for the treatment of COVID-19 that retains activity against
the omicron variant.
The EUA for Bebtelovimab is for the treatment of mild to moderate COVID-19 in
adults and pediatric patients (12 years of age and older we...
The COVID-19 Treatment Guidelines:
On December 22 and 23, 2021, the
Food and Drug Administration (FDA) issued Emergency Use Authorizations (EUAs)
that allow 2 new oral antiviral agents to be used in this patient population:
ritonavir-boosted nirmatrelvir and molnupiravir.
Ritonavir-Boosted Nirmatrelvir
Nirmatrelvir is an orally bi...
Journal of Neuro-Ophthalmology:
TAKE-HOME MESSAGE
This study reviewed
published literature regarding the ophthalmic manifestations of
COVID-19. Findings revealed that eye pain was caused by conjunctivitis,
episcleritis, scleritis, and optic neuritis, and headache was the result
of trigeminal nerve invasion and vascular effects. These mani...
