Practice-updates

Nonpharmacologic measures Patients should be encouraged to wear loose-fitting garments made of cotton or synthetic materials designed to wick moisture away from the surface. Socks should have similar properties. Areas likely to become infected should be dried completely before being covered with clothes. Patients should also be advis...
JAMA Neurology: Early and prodromal features of Parkinson disease (PD) have increasing relevance as the quest for potential disease-modifying therapies is expanding. KEY TAKE-HOME MESSAGE Question What are the prediagnostic manifestations of Parkinson disease (PD) presented in the primary care setting? Findings This case-contr...
Take Home Messages: Authors propose a new conceptual model for PD pathogenesis, in which disease-associated factors are divided into three categories: triggers, facilitators, and aggravators. Triggers are agents or events that begin the disease process; these factors are necessary but insufficient for PD to develop. Facilitators ar...
High blood pressure is the leading cause of mortality and cardiovascular disease globally, and most of the disease burden occurs in low- and middle-income countries. Recent guidelines recommend lower blood pressure targets among high-risk patients, increasing the need for more effective treatment strategies.Treatment with a pill combining low...
Worldwide, cardiovascular diseases (CVDs) Source are one of the leading causes of death. Every year, an estimated 17.9 million people around the world die as a result of complications from heart diseases. For context, this means that CVDs are responsible for 32% of all deaths globally.Prior studies Source show that various factors — such as se...
Reflux esophagitis is an esophageal mucosal injury that occurs secondary to retrograde flux of gastric contents into the esophagus. Clinically, this is referred to as gastroesophageal reflux disease (GERD).Fig: EsophagitisWhich PPI is Superior?Some of the present study demonstrated that Esomeprazole gave faster symptom relief in patients with R...
Key Points about Vitamin D Deficiency and Dependency Vitamin D deficiency is common and results from inadequate exposure to sunlight and inadequate dietary intake (usually occurring together) and/or from chronic kidney disease.   The deficiency can cause muscle aches and weakness, bone pain, and osteomalacia....
Therapeutic indicationsAmoxicillin, alone or in combination with clavulanic acid, still accounts among the most widely used antibacterial agents. Although they are often considered 'twin drugs', they are different both in terms of antibacterial activities and of safety profile.Amoxicillin/clavulanate potassium is indicated in the treatment of i...
Cefuroxime is a 2nd generation cephalosporin group of broad-spectrum β-lactam antibiotic.Clavulanic acid is a beta lactamase inhibitor used to enhance the effectiveness of beta lactam antibiotics. Clavulanic acid does have some degree of bacterial activity; its principal role is as a beta-lactamase inhibitor. Used in combination with t...
The following groups are at a particularly high risk of vitamin D deficiency:Infants and children aged 65 yearsIndividuals who have darker skin (e.g. people of South Asian ethnic origin).People who have no or limited sun exposure, including people who:  cover their skin for cultural reasons are confined in...
A Double Action Antacid & Alginate Liquid was more effective than an antacid in controlling postprandial esophageal acid exposure in GERD patients. This suggests that this main effectiveness related to its co-localization with and displacement/neutralization of the post-prandial acid pocket, rather than preventing reflux.Heartburn is...
Esomeprazole Dose - 20mg/40mg WHEN, HOW and WHY?Esomeprazole is a proton pump inhibitor used to -·        treat GERD, ·        reduce the risk of NSAID associated gastric ulcers, ·        eradicate H. pylori, and · ...