Reflux esophagitis is an esophageal mucosal injury that occurs secondary to retrograde flux of gastric contents into the esophagus. Clinically, this is referred to as gastroesophageal reflux disease (GERD).

Fig: Esophagitis

Which PPI is Superior?

Some of the present study demonstrated that Esomeprazole gave faster symptom relief in patients with Reflux Esophagitis than pantoprazole, lansoprazole and omeprazole. 

Esomeprazole can effectively relieve symptoms of esophagitis (e.g., heartburn) and promote healing of ulcerative and erosive lesions. Because esomeprazole (S-omeprazole) is not eliminated as rapidly as R-omeprazole, more drug reaches and blocks the proton pump, providing greater control of intragastric pH than racemic omeprazole.

Because:

Esomeprazole has been shown to have a faster onset of anti-secretory activity than omeprazole, lansoprazole and pantoprazole.

In conclusion, the present study found that esomeprazole 40 mg daily may be more effective than either omeprazole 20 mg daily, pantoprazole 40 mg daily or lansoprazole 30 mg daily for the rapid relief of heartburn symptoms in patients with endoscopically proven reflux esophagitis.

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