Cardiovascular-disorders

Efficacy and Safety of a Novel Low-Dose Triple Single-Pill Combination for Initial Hypertension Treatment
Journal of the American College of Cardiology: August, 2024Single-pill combinations of 3 or more low-dose blood pressure (BP)-lowering drugs hold promise for initial or early treatment of hypertension.The Authors conducted a placebo-controlled trial of a new single-pill combination containing low doses of telmisartan, amlodipine, and indapamid...
Effects of Statin Therapy on Diagnoses of New-Onset Diabetes and Worsening Glycaemia
The Lancet Diabetes & Endocrinology: Published: March, 2024Atherosclerotic cardiovascular disease is a leading cause of death worldwide, and LDL cholesterol is a major causal risk factor.Diabetes substantially increases the risk of atherosclerotic cardiovascular disease.TAKE-HOME MESSAGEIn this participant-level meta-analysis of 19 trials, sta...
Hypertension Management Guidelines
Management of hypertensionMany guidelines exist for the management of hypertension. Most groups, including the JNC, the American Diabetes Associate (ADA), and the American Heart Association/American Stroke Association (AHA/ASA) recommend lifestyle modification as the first step in managing hypertension.Lifestyle modificationsJNC 7 recommendation...
Effective management of Hypertension with Additional Risk Factors - Global Hypertension Practice Guidelines
The 2020 Global Hypertension Practice Guidelines were developed by the International Society of Hypertension (ISH) Guidelines Committee based on evidence criteria to be used globally. RemoveIn addition to BP control, the therapeutic strategy should include lifestyle changes, body weight control and the effective treatment of the other risk fac...
Associations of Testosterone and Related Hormones with Cardiovascular Mortality and Incident Cardiovascular Disease in Men
Annals of Internal Medicine: Published May 2024Testosterone (T) levels slowly decline as we age, and serum hormone-binding globulin (SHBG) levels gradually increase. As SHBG increases, there is less T available to the tissues. There are several conditions that reduce levels of T; these include being overweight, having metabolic dysfunction, liv...
Lipid-Lowering Therapy after an Acute Myocardial Infarction in Older Adults: 5-Year Outcomes
Circulation: Cardiovascular Quality and Outcomes: Published Apr 2024TAKE-HOME MESSAGEThis study used data from the FAST-MI program to examine the effect of lipid-lowering therapy (LLT) (atorvastatin ≥40 mg or equivalent or any combination of a statin and ezetimibe) intensity on long-term mortality in 2258 patients aged 80 years or older who ex...
Association between Tomato Consumption and BP in an Older Population at High Cardiovascular Risk
Clinical studies have produced conflicting evidence on the effects of the consumption of tomatoes on blood pressure, and there are limited data from epidemiologic studies. This study assesses whether tomato consumption (Solanum lycopersicum L.) is associated with Systolic (SBP) and Diastolic Blood Pressure (DBP), and the risk of hypertension i...
Effect of Initial Treatment with Quadpill vs Standard Dose Monotherapy in Patients with Hypertension
Circulation: AHA Journals: Published July, 2023Hypertension management remains suboptimal globally, with treatment inertia being identified as one of the main barriers to achieving blood pressure (BP) control. Simpler approaches to achieve target BP levels are needed. TAKE-HOME MESSAGEThe QUARTET study examined the effectiveness of a quadrupl...
Association of Hypertensive Disorders of Pregnancy with Cardiovascular Diseases within 24 Months after Delivery
American Journal of Obstetrics & Gynecology: Published: April, 2023Hypertensive disorders in pregnancy (HDPs) are major causes of maternal and fetal morbidity and are associated with future maternal risk of cardiovascular disease.Most existing data on hypertensive disorders of pregnancy and short-term cardiovascular disease risks are limited t...
Aspirin vs Clopidogrel for Chronic Maintenance Monotherapy after PCI: Long-Term Outcomes
AHA Journals (Circulation): Published on November, 2022Once patients have completed their dual antiplatelet therapy, we need to stop one of the medications — which one — ASA or clopidogrel? For many of us, we will keep the ASA and get rid of the other agent like clopidogrel.This study in Korea included 5438 patients who had PCI with drug-elutin...
Chlorthalidone vs Hydrochlorothiazide for Hypertension-Related Cardiovascular Events
The New England Journal of Medicine: Published on December, 2022Hypertension increases the risk of complications and death from cardiovascular disease. Thiazide diuretics are first-line antihypertensive agents that lower blood pressure and prevent adverse cardiovascular outcomes. Early studies suggested that chlorthalidone was superior to hydro...
Triple Combination Antihypertensive Therapy VS Usual Care and Time at Maintaining Target Blood Pressure
JAMA Cardiology: Published on April, 2022TAKE-HOME MESSAGEQuestion:  Is low-dose triple combination antihypertensive therapy associated with greater time at target blood pressure compared with usual care?Findings:  This secondary analysis of an open-label randomized controlled clinical trial evaluated whether low-dose triple combination antihyp...