Drug-highlights

Gastro-esophageal reflux disease (GERD) is a disorder involving troublesome symptoms associated with persistent reflux of gastric contents into the esophagus. Symptoms include heartburn, cough, epigastric pain, vomiting, and regurgitation.GERD is proposed to have 5 distinct presentations—nonerosive GERD (NERD), erosive esophagitis (EE), functio...
Mycoses Journal: Published on April 2021Dermatomycoses of zoophilic origin, especially those caused by Trichophyton mentagrophytes, often pose considerable therapeutic problems. This is reflected in the growing number of strains of this species with resistance to terbinafine caused by a mutation in the squalene epoxidase (SQLE) gene. TAKE HOME...
Neurology: August, 2023Cumulative use of proton pump inhibitors (PPIs) for more than 4.4 years is associated with an increased risk for dementia, according to a study published in Neurology.TAKE-HOME MESSAGEThis study evaluated whether the current and cumulative use of proton pump inhibitors (PPIs) are associated with a higher risk of incident...
Clinical Gastroenterology and Hepatology: February, 2022The incidence rate of hepatocellular carcinoma (HCC) has been increasing for the last 3 decades. Fatty liver progresses from fat accumulation to inflammation to fibrosis to cirrhosis to cancer. Recent evidence suggests potential clinical benefits of statin in cancer chemoprevention a...
AGA Journals (Gastroenterology): June, 2023Chronic idiopathic constipation (CIC) is a common disorder associated with significant impairment in quality of life. This clinical practice guideline, jointly developed by the American Gastroenterological Association and the American College of Gastroenterology, aims to inform clinicians and patients...
Reviews in Endocrine and Metabolic Disorders: Published: August 2021Endometriosis is a chronic disease characterized by the presence of endometrium-like tissue outside the uterine cavity, affecting women of reproductive age with pelvic pain and infertility deeply affecting women’s health. The most common symptoms of endometriosis are menstruat...
American Journal of Ophthalmology: Published May, 2023Glaucoma is a disease characterized by progressive deterioration of the optic nerve and retinal nerve fiber layer (RNFL) defect with corresponding visual field changes.Globally, both the prevalence of chronic kidney disease (CKD) and glaucoma are rising rapidly. These 2 diseases share a comm...
JAMA Network: November, 2019Proton pump inhibitors (PPIs) are drugs widely prescribed to reduce gastric acidity. Although they are considered globally safe, observational studies have reported significant adverse effects associated with their long-term use, such as osteoporotic-related fractures, vitamin B12 deficiency, kidney disease, or...
Tinea (pityriasis) versicolor is a superficial fungal infection and one of the most commonly found pigmentary disorders of skin caused by the yeast Malassezia. Multiple topical as well as systemic therapies are available for treatment. Systemic therapies are used for extensive disease, frequent relapse or where topical agents have failed. TAKE...
Human Reproduction Update Journal: Published on February, 2019Subclinical hypothyroidism (SCH) is defined as an elevated serum thyrotropin (TSH) level with normal serum thyroxine (T4) level and affects 3–8% of women of childbearing age. International guidelines advocate the use of population-based reference ranges of TSH during pregnancy; h...
CHRISMED Journal of Health and Research: Published on 2019Dysfunctional uterine bleeding (DUB) is excessive uterine bleeding which is not attributed to pregnancy or any detectable uterine or systemic pathology. Patients suffering from DUB commonly complain about heavy menstrual bleeding (HMB), irregular bleeding, spotting between periods, or s...
eClinicalMedicine Journal: The LANCET: Published on December, 2022Gram-negative bacteremia is common in both community and health care settings, with a significant increase in incidence described for some Gram-negative bacteria in recent years.Prolonged duration of antibiotic therapy for such common infections may lead to increased resistance em...