Neurologic-disorders
American Epilepsy Society issues
guideline and treatment algorithm for convulsive status epilepticus. The
guideline was endorsed by the Epilepsy Foundation, Child Neurology Society, and
American College of Emergency Physicians.Status epilepticus – continuous or rapid sequential seizure activity for
30 minutes or more – is a medical emergency wi...
Updated Systematic Review and Meta-analyses:Bipolar disorder (formerly called manic depression) is a mood
disorder characterized by periods of depression and periods of
abnormally-elevated mood.Valproate is an anticonvulsant drug that is frequently used
in maintenance treatment of bipolar disorder. Clinicians and patients should
consider accept...
Parkinson's disease (PD) is a progressive, neurodegenerative
disorder of aging that affects both motor and cognitive function. The etiology
of PD is mostly unknown, but it likely involves both genetic and environmental
factors.Recognizing early symptoms of Parkinson'sNonmotor symptoms:Nonmotor symptoms are common in early Parkinson disease. The...
A Report
of the American Academy of Neurology (AAN) Guideline Subcommittee:Levodopa preferred as initial dopaminergic therapy for motor symptoms in
patients with early Parkinson disease.Parkinson
disease (PD) is a neurodegenerative disorder that causes both motor and
nonmotor symptoms and increases in prevalence with age. Motor symptoms in the...
JAMA NeurologyTAKE-HOME MESSAGE
Evidence is rapidly accumulating of
the benefit of exercise and physical activity in Parkinson disease (PD). The
authors conducted a nationwide population-based cohort study of 10,699
individuals with PD, evaluating the association of physical activity (obtained
from self-reported structured questionnaires...
Generalized anxiety disorder (GAD)
is the most common mental disorders. The hallmark of GAD is excessive,
out-of-control worry. This condition can negatively impact a patient's quality of
life and disrupt important activities of daily living. Women are twice as
likely as men to have the disorder. It often begins in childhood or adolescence...
Motor symptoms are those that
affect movement of the body. These are the cardinal symptoms of PD. The main
motor symptoms of PD are tremor, slowness of movement (bradykinesia), stiffness
(rigidity), and poor balance (postural instability). These symptoms are usually
mild in the early stages of the disease. PD patients show additional mo...
NICE guideline:
Suspect
Parkinson's disease in people presenting with tremor, stiffness, slowness,
balance problems and/or gait disorders.
If
Parkinson's disease is suspected, refer people quickly and untreated to a
specialist with expertise in the differential diagnosis of this condition.
Clinical diagnosis
Diagnose
Parkinso...
Introduction
Parkinson’s disease (PD) is a
neurodegenerative disease resulting from progressive death of the dopaminergic
neurons in the brainstem, particularly the substantia nigra pars compacta
(SNc). Besides the hallmark motor symptoms (hypokinesia, rest tremor, rigidity,
and postural instability), PD patients have non-motor symptoms...
JAMA: The Journal of the American Medical Association: Published
on April 5, 2022
Epilepsy affects approximately 65
million people worldwide. Persistent seizures are associated with a 20% to 40%
risk of bodily injuries (eg, fractures, burns, concussions) over 12-month
follow-up. The primary goal of epilepsy treatment is to eliminate seiz...
The New England Journal
of Medicine (NEJM): Published
on July 15, 2021
The incidence rate of a single unprovoked seizure among
adults is 23 to 61 cases per 100,000 person-years.
After a first unprovoked seizure, the overall risk of
recurrence may be as high as 60%, and this risk is highest within the first 2
years.
Epilepsy is...
JAMA Neurology:
Early and prodromal features of
Parkinson disease (PD) have increasing relevance as the quest for potential
disease-modifying therapies is expanding.
KEY TAKE-HOME MESSAGE
Question What
are the prediagnostic manifestations of Parkinson disease (PD) presented in the
primary care setting?
Findings This
case-contr...
