Endocrine-disorders

2-Year Effects of Semaglutide in Adults with Overweight or Obesity
Nature Medicine: Published on November, 2022Obesity is a chronic, relapsing disease with a substantial morbidity, mortality, and healthcare burden. Drug interventions for the treatment of obesity provide a potential valuable adjunct to lifestyle interventions, which often achieve only limited weight loss that is difficult to maintain. Semagluti...
FDA Approves First Drug That Can Delay Onset of Type 1 Diabetes
FDA News Release: Published on November, 2022Type one diabetes mellitus (T1DM) is an autoimmune disease characterized by gradual destruction of beta cells in islets of Langerhans. Teplizumab is a humanized anti- CD3 monoclonal antibody, which have beneficial effects for T1DM patients.The U.S. Food and Drug Administration (FDA) has approved tepl...
Risk of Incident Diabetes after COVID-19 Infection
Coronavirus disease 2019 (COVID-19) is one of the most significant pandemics in human history caused by the virus known as severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). SARS-CoV-2 has infected >530 million people, of which >6.3 million have died since June 23, 2022. Recent research has indicated that COVID-19 might be a risk fa...
2-Year Effects of Semaglutide in Adults with Overweight or Obesity
Nature Medicine: Published on November, 2022Obesity is a chronic, relapsing disease with a substantial morbidity, mortality, and healthcare burden. Drug interventions for the treatment of obesity provide a potential valuable adjunct to lifestyle interventions, which often achieve only limited weight loss that is difficult to maintain. Semagluti...
Effectiveness and Safety of Intermittent Fasting in People with Insulin-Treated Type 2 Diabetes
Diabetes Care: Published on December 2022With the numbers of people with type 2 diabetes rising worldwide, dietary modifications provide an essential therapeutic approach for blood glucose, weight, and cardiovascular risk-factor management. Intermittent fasting (IF) has emerged as an alternative to classic daily caloric reduction. The approache...
Vitamin D and the Risk for Type 2 Diabetes in People with Prediabetes
ACP Journals: Annals of Internal Medicine: Published on February 2023In this systematic review and meta-analysis, the authors assessed whether vitamin D administration decreases the risk for diabetes in individuals with prediabetes. TAKE-HOME MESSAGECombining data from three randomized trials, the authors demonstrated that vitamin D reduced the...
Oral Contraceptive Use, Hormone Replacement Therapy, and Stroke Risk
AHA Journal: Stroke: A Journal of Cerebral Circulation: Published on June, 2022Millions of women worldwide use exogenous hormones as oral contraceptives or hormone replacement therapy. Still, time-dependent and long-term consequences of exogenous hormones on stroke risk remains unclear.TAKE-HOME MESSAGEIn this UK Biobank analysis including 257,...
Safety and Efficacy of Oral Insulin in Patients with Early-Stage Type 2 Diabetes
Diabetes, Obesity & Metabolism Journal: Published on November, 2022TAKE-HOME MESSAGEThis open-label randomized trial assessed the safety and efficacy of oral insulin (Capsulin) in patients with poorly controlled type 2 diabetes on metformin alone. Participants on the 150-IU and 300-IU dose of oral insulin saw a significant decrease in HbA1c lev...
Gestational Glucose Intolerance and Risk of Future Diabetes
Diabetes Care Journal: Published on January 2023Gestational diabetes (GDM) is a complex disorder associated with adverse fetal and maternal outcomes. GDM is a global problem and has an estimated prevalence of 14%. The term gestational glucose intolerance (GGI) is applied to women who have an abnormal screening 50-g glucose challenge test (...
Combination vs Standard Mono Therapy Using Metformin for Patients with Untreated Type 2 Diabetes
Diabetes Research and Clinical Practice: Published on July, 2022The American Diabetes Association recommends that metformin should be started at the time of type 2 diabetes mellitus (T2DM) diagnosis, unless there are contraindications. Metformin is safe, effective, economic, and might reduce the risk of cardiovascular events and death. When gl...
Subchorionic Hematoma accounts for 20% of all bleeding during the 1st trimester of pregnancy
Any type of bleeding during pregnancy can be alarming. About 25% of women experience some bleeding or spotting during their pregnancy. Subchorionic hematomas are the cause of about 20% of all bleeding during the first trimester. This is a type of bleeding that occurs between amniotic membranes. It occurs when the placenta partially detaches...
Effect of Dydrogesterone and Progesterone on threatened miscarriage due to corpus luteum insufficiency
PubMed Central: IntroductionThreatened miscarriage is a common disease during early pregnancy, with a morbidity of 30% to 40%, which could develop into a complete miscarriage or dystocia without timely treatment. Many pathogenic factors contribute to the threatened miscarriage, of which lacking progestogens due to the endocrine dysfunction of...