Key facts Antibiotic resistance is one of the biggest threats to global health, food security, and development today. Antibiotic resistance can affect anyone, of any age, in any country. Antibiotic resistance occurs naturally, but misuse of antibiotics in humans and animals is accelerating the process. A gr...

First-generation cephalosporins have active coverage against·        Gram-positive cocci such as staphylococci spp. and streptococci spp. while having minimal coverage against gram-negative bacteria.·        Gram-negative bacteria that are somewhat susceptible to first-generation cephalosporins are Proteus mirabilis, E. coli, and Klebsiella pn...