First-Generation Cephalosporin’s Bacterial Coverages and Treatment Indications

First-generation cephalosporins have active coverage against

· Gram-positive cocci such as staphylococci spp. and streptococci spp. while having minimal coverage against gram-negative bacteria.

· Gram-negative bacteria that are somewhat susceptible to first-generation cephalosporins are Proteus mirabilis, E. coli, and Klebsiella pneumoniae.

Examples of first-generation cephalosporins:

Oral

Cephalexin
Cephradine
Cefadroxil

Parental

Cefazolin (intravenous and intramuscular)

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First-generation cephalosporins used to treat

Note: Parenteral Cefazolin is the cephalosporin of choice for surgical prophylaxis before cardiothoracic, orthopedic, abdominal, and pelvic surgery.

The prevalence of MRSA has diminished the efficacy of first-generation cephalosporins as a means of prophylaxis and treatment.

Source

https://www.ncbi.nlm.nih.gov/books/NBK551517/

https://www.ncbi.nlm.nih.gov/books/NBK549881/

https://www.healthline.com/health/cephalosporins

https://www.sciencedirect.com/science/article/abs/pii/S0025712516314523

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This is for informational purposes only. You should consult your clinical textbook for advising your patients.