Clinical-spotlight
The U.S. Food and Drug
Administration approved the emergency use of the molnupiravir pill for the
treatment of mild-to-moderate coronavirus disease 2019 in nonhospitalized adult patients with positive
results of direct SARS-CoV-2 viral testing who are at high risk for progressing
to severe COVID-19, including hospitalization or death.Does molnu...
NICE guidelines:Take Home MessagesDo not offer an antibiotic
for preventing or treating Pneumonia if SARS-CoV-2, another virus, or a fungal
infection is likely to be the cause.Evidence as of March 2021
suggests that bacterial co-infection occurs in less than about 8% of people
with COVID-19, and could be as low as 0.1% in people in hospital wit...
Nirmatrelvir and Ritonavir is the
first oral agent authorized by FDA (Emergency Use Authorization) for treatment
of mild-to-moderate coronavirus disease in adults and
pediatric patients.
In a randomized, double-blind,
placebo-controlled clinical trial, Nirmatrelvir and Ritonavir significantly
reduced the proportion of people with COVI...
NICE guidelines:Antibiotic treatment in the communityRecommendationsDo not offer an antibiotic for
preventing secondary bacterial pneumonia in people with COVID 19. If a person has suspected or
confirmed secondary bacterial pneumonia, start antibiotic treatment as soon as
possible. Advise people to seek medical help
without delay if their sympt...
The U.S. Food and Drug
Administration (USFDA) issued an emergency use authorization (EUA) for a new
monoclonal antibody for the treatment of COVID-19 that retains activity against
the omicron variant.
The EUA for Bebtelovimab is for the treatment of mild to moderate COVID-19 in
adults and pediatric patients (12 years of age and older we...
The American Journal of
Gastroenterology
Gastroesophageal
reflux disease (GERD) continues to be among the most common diseases seen by
gastroenterologists, surgeons, and primary care physicians.
GERD is
the condition in which the reflux of gastric contents into the esophagus
results in symptoms and/or complications. GERD is defined b...
From The Journal of Infectious Diseases and
The British Medical Journal:
Sepsis mortality has improved
following advancements in early recognition and standardized management, including
emphasis on early administration of appropriate antimicrobials. However,
guidance regarding antimicrobial duration in sepsis is surprisingly limited....
JAMA Surgery:
Surgical
site infections (SSIs) are infections of the incision or organ or space that
occur after surgery. Surgical patients initially seen with more
complex comorbidities and the emergence of antimicrobial-resistant pathogens
increase the cost and challenge of treating SSIs. The prevention of SSI is
increasingly important...
European Heart Journal: Published: 10 July 2022
Adding salt to foods (usually at
the table) is a common eating behavior directly related to an individual's
long-term preference to salty taste foods and habitual salt intake. Indeed, in
western diet, adding salt at the table accounts for 6–20% of total salt intake.
In addition, the com...
American Epilepsy Society issues
guideline and treatment algorithm for convulsive status epilepticus. The
guideline was endorsed by the Epilepsy Foundation, Child Neurology Society, and
American College of Emergency Physicians.Status epilepticus – continuous or rapid sequential seizure activity for
30 minutes or more – is a medical emergency wi...
Hormone therapy is the most
effective treatment for vasomotor symptoms (VMS) and other menopausal symptoms.
Changing estrogen levels during menopause may impact multiple components
involved in maintaining temperature homeostasis.Health care professionals should
individualize therapy based on clinical factors and patient preference. They
should...
Paracetamol has often been cited as
a safer alternative to non-steroidal anti-inflammatory drugs (NSAIDs) with
regards blood pressure and cardiovascular health. But now researchers have
raised concerns about this, suggesting that those taking paracetamol long-term
may be at greater risk of heart attack and stroke.Long-term paracetamol use could...
