Medical management of GERD mainly
uses proton pump inhibitors. Alginates plus Antacids also have proven efficacy.
Tolerance and safety were good and comparable in both groups.
Alginates plus Antacids was
non-inferior to omeprazole in achieving a 24-h heartburn-free period in
moderate episodic heartburn, and is a relevant effective alternative treatment
in moderate GERD in primary care.
Combined antacid–alginic acid preparations have been shown to be more effective than placebo in relieving GERD symptoms, based on measures such as lower global symptom scores, less acid regurgitation, and fewer days and nights with heartburn.
Proton pump inhibitors —
Stronger relief
But Alginate plus Antacids —
for Quicker relief
H2 blockers and proton pump
inhibitors work better than antacids, but if patient need very quick relief,
antacids are an option. Antacids don’t do anything to prevent GERD, but they
can be used on demand for symptom relief.
Side effects of antacids are mild and include constipation, nausea, and diarrhea. Don’t overuse them: Some brands contain calcium, and too much calcium can lead to kidney stones.
Note: Any treatment for acid reflux should be accompanied by diet
and lifestyle changes. Aim for no late night eating, elevating your head in bed
at night, getting enough sleep, and so on.
If symptoms continue for more
than 2 weeks with an antacid, patient may need additional medication. If
the patient’s heartburn is severe, the patient could be started on PPI therapy.
https://www.nice.org.uk/guidance/GID-NG10096/documents/evidence-review-10
https://www.iersurgery.com/general/the-different-stages-of-gerd/
https://www.goodrx.com/blog/best-treatment-acid-reflux-antacids-h2-blockers-proton-pump-inhibitors/
https://www.medscape.com/viewarticle/763058
https://bmcgastroenterol.biomedcentral.com/articles/10.1186/1471-230X-12-18
https://pubmed.ncbi.nlm.nih.gov/28375448/
https://pubmed.ncbi.nlm.nih.gov/26909885/
https://pubmed.ncbi.nlm.nih.gov/22361121/
https://houstonheartburn.com/four-stages-of-gerd/
https://www.aafp.org/afp/1999/0301/p1161.html
https://www.sciencedaily.com/releases/2007/12/071208145406.htm
Note: For
informational purposes only. Consult your textbook for advising your patients.
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