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Neurogastroenterology and Motility Journal: Published:
September 2022GERD is a condition that develops
when the reflux of stomach contents causes troublesome symptoms and/or
complications. These symptoms include typical ones, such as heartburn,
regurgitation, or both, angina-mimicking non-cardiac chest pain, and
extra-esophageal symptoms,...
BMJ Open: Published, October, 2023This study aimed to investigate the
potential association between PPI use and kidney stones by analysing National
Health and Nutrition Examination Survey (NHANES) data from 2007 to 2018. TAKE-HOME MESSAGEThe authors
of this large US-based cross-sectional study found that proton-pump inhibitor
(PPI) use was asso...
Neurology: August, 2023Cumulative use of proton pump
inhibitors (PPIs) for more than 4.4 years is associated with an increased risk
for dementia, according to a study published in Neurology.TAKE-HOME MESSAGEThis study
evaluated whether the current and cumulative use of proton pump inhibitors
(PPIs) are associated with a higher risk of incident...
JAMA Network: November, 2019Proton pump inhibitors (PPIs) are
drugs widely prescribed to reduce gastric acidity. Although they are considered
globally safe, observational studies have reported significant
adverse effects associated with their long-term use, such as
osteoporotic-related fractures, vitamin B12 deficiency, kidney
disease, or...
Eosinophilic esophagitis (EoE) is an
immune/antigen-mediated, progressive fibrostenotic disease characterized by
symptoms of esophageal dysfunction and abnormal eosinophilic infiltration in
the esophagus. Despite treatment modalities of
dietary antigen elimination or Topical corticosteroids, a subset of patients do
not have clinical or histolo...
Gastroesophageal reflux disease
(GERD) continues to be among the most common diseases seen by
gastroenterologists, surgeons, and primary care physicians. The American College of Gastroenterology (ACG) recently
released an updated guideline on diagnosis and management of GERD which was
published by the American Journal of
Gastroenterology. In t...
Acute
upper gastrointestinal bleeding (AUGIB) is a common medical emergency. In
Western countries, its incidence was estimated to be over 100 cases per 100 000
adults per year. Fortunately, the mortality rates of AUGIB have decreased over
the past few decades, largely attributable to improvements in endoscopic and
pharmacological therapies...
Alimentary Pharmacology & Therapeutics:
Functional dyspepsia is
characterised by troublesome early satiety, fullness, or epigastric pain or
burning. It can easily be overlooked as the symptoms overlap with
gastro-oesophageal reflux disease and irritable bowel syndrome.
It affects 10% of the population
and is more prevalent in women....
Proton Pump Inhibitors (PPIs) are widely considered the
mainstay of medical treatment for GERD. Multiple publications have raised questions about adverse
events, raising doubts about the safety of long-term use and increasing concern
about overprescribing of PPIs. This guideline provides updated, evidence-based recommendations and
practical...
Indian Journal of Gastroenterology: Published:
30 June 2022
TAKE HOME MESSAGE:
Nocturnal acid breakthrough (NAB)
may differ based on duration of proton pump inhibitor (PPI) action and Helicobacter
pylori (H. pylori) infection; NAB may influence esophageal
acidification (EA) and mucosal damage.
Dexlansoprazole, a long-acting PPI,...
A Systematic Review and
Meta-analysisGastroesophageal reflux disease (GERD) is a chronic digestive
disorder resulting from the reflux of gastric contents into the esophagus that
is often accompanied by troublesome symptoms of heartburn, acid regurgitation,
or other extra-esophageal symptoms such as chest pain, chronic cough,
hoarseness or glob...
Clinical Gastroenterology and Hepatology
TAKE-HOME MESSAGE
This review presents best practice
advice statements to help healthcare providers in the treatment of patients
with gastroesophageal reflux disease (GERD).
To optimize care and response,
diagnostic testing should be personalized and management should be tailored to
the ind...
