Usual Adult Dose for Fever

Oral:

Doses may be given as a single or repeated dose as follows:

Immediate-release: 325 mg to 1 g orally every 4 to 6 hours

• Minimum Dosing Interval: every 4 hours
• Maximum Single Dose: 1000 mg
• Maximum Dose: 4 g/24 hours

Extended-Release: 1300 mg orally every 8 hours

• Maximum dose: 3900 mg per 24 hours

Usual Adult Dose for Pain

Doses may be given as a single or repeated dose as follows:

Oral:

Immediate-release: 325 mg to 1 g orally every 4 to 6 hours

• Minimum Dosing Interval: every 4 hours
• Maximum Single Dose: 1000 mg
• Maximum Dose: 4 g per 24 hours

Extended-Release: 1300 mg orally every 8 hours

• Maximum dose: 3900 mg/24 hours

Caution:

Hepatotoxicity has been reported at doses within the therapeutic range of paracetamol (in some cases at doses less than the recommended 4 g/day).

Source:

US Food and Drug Administration. New steps aimed at cutting risks from acetaminophen. Silver Spring, Maryland: US Food and Drug Administration, 2011. [Online] (accessed 27 April 2015).

US Food and Drug Administration. Acetaminophen information. Maryland: US Food and Drug Administration, 2015. [Online] (accessed 1 May 2015).

Australian Medicines Handbook. Paracetamol. Adelaide: AMH Ltd, 2015. [Online] (accessed 27 April 2015).

Australian Institute of Health and Welfare. National drug strategy household survey detailed report. Canberra: Australian Institute of Health and Welfare, 2014. [Online] (accessed 27 April 2015).