Esomeprazole provides greater acid control compared to Omeprazole

Esomeprazole is the S-isomer of Omeprazole and reduces gastric acid secretion through a specific targeted mechanism of action. It is a specific inhibitor of the acid pump in the parietal cell.

Esomeprazole works better to lower acidity in the gut and improve symptoms of GERD compared to omeprazole. How?

Find out below:

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Is Esomeprazole better than Omeprazole?

What researchers found?

Compared to Omeprazole, Esomeprazole provides greater acid control in patients with GERD and keeps stomach pH at higher than 4 for a longer period of time (Since higher the pH level is associated with prompt resolution of GERD symptoms and high rates of esophagitis healing.

It also exerts a faster rise of intragastric pH environment than omeprazole by inhibiting the proton pump of gastric mucosa.

Compared with omeprazole, its S-isomer esomeprazole displays lower first-pass hepatic metabolism and slower plasma clearance; this results in higher plasma concentration and highly effective inhibition of gastric acid secretion.