Comparative study of PPI for symptom relief in patients with reflux esophagitis:

Some of the present study demonstrated that esomeprazole gave faster symptom relief than pantoprazole, lansoprazole and omeprazole.

Because:

• Esomeprazole has been shown to have a faster onset of anti-secretory activity than omeprazole, lansoprazole and pantoprazole.
• In conclusion, the present study found that esomeprazole 40 mg daily may be more effective than either omeprazole 20 mg daily, pantoprazole 40 mg daily or lansoprazole 30 mg daily for the rapid relief of heartburn symptoms in patients with endoscopically proven reflux esophagitis.
• Symptom relief after several days of treatment and reflux esophagitis healing rates after 8 wks. of treatment, were not different between patients treated with omeprazole, pantoprazole, lansoprazole, or esomeprazole.

REFERENCES

• https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5221858/
• Targownik L. Discontinuing long-term PPI therapy: why, with whom, and how? Am J Gastroenterol 2018; 113:519–528.
• Zheng RN. Comparative study of omeprazole, lansoprazole, pantoprazole and esomeprazole for symptom relief in patients with reflux esophagitis. World J Gastroenterol 2009; 15(8): 990-995