Posted by ACI Limited
Omicron driving spike in new Covid-19 cases in Bangladesh
recently and expected to rise in coming days according to health officials. The Covid-19 positivity rate in Bangladesh has reached the
highest-ever 33.37% in last week. The health authorities recorded 15,440 new infections after
testing 46,268 samples across the country. The latest figure...
Nirmatrelvir and Ritonavir is the
first oral agent authorized by FDA (Emergency Use Authorization) for treatment
of mild-to-moderate coronavirus disease in adults and
pediatric patients.
In a randomized, double-blind,
placebo-controlled clinical trial, Nirmatrelvir and Ritonavir significantly
reduced the proportion of people with COVI...
The COVID-19 Treatment Guidelines:
On December 22 and 23, 2021, the
Food and Drug Administration (FDA) issued Emergency Use Authorizations (EUAs)
that allow 2 new oral antiviral agents to be used in this patient population:
ritonavir-boosted nirmatrelvir and molnupiravir.
Ritonavir-Boosted Nirmatrelvir
Nirmatrelvir is an orally bi...
The New England Journal of Medicine
Real-world studies have shown the
short-term effectiveness of vaccines with respect to symptomatic and
asymptomatic severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infections,
the severity of Covid-19, and secondary transmission. The duration of this
protection over longer periods remains...
The New England Journal of Medicine
Infection
with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and illness
with the associated coronavirus disease 2019 (Covid-19) continue to threaten
global health.
Persons
with particular characteristics such as older age, current smoking, or
underlying clinical conditions such as...
JAMA Internal Medicine:
Key Points
Question What
is the risk of perinatal complications associated with SARS-CoV-2 infection
during pregnancy and what factors are associated with hospitalizations?
Findings In
this cohort study of 43 886 pregnant individuals, SARS-CoV-2 infection during
pregnancy was associated with an increased ris...
BMJ: British Medical Journal
This
retrospective case series analysis compared the incidence of immune-mediated
neurologic events among over 8 million individuals vaccinated against COVID-19,
over 700,000 unvaccinated individuals diagnosed with COVID-19, and a historical
cohort of over 14 million individuals in the general population....
American Journal of Obstetrics and Gynecology:
Key findings
Vaccine-generated antibodies were
present in umbilical cord blood and breastmilk after maternal vaccination.
Pregnant and lactating women
elicited comparable vaccine-induced humoral immune responses with nonpregnant
controls and generated higher antibody titers than those o...
American College of Physicians (ACP) Journals: Annals of Internal
Medicine
Nirmatrelvir–ritonavir (NMV/r) is use in high-risk patients with
mild to moderate COVID-19 who are likely to be receiving other medications. NMV/r
administered within three days of symptom onset reduced the risk of COVID-19
related hospitalization and death from a...
European Heart Journal:
Emerging as a new epidemic, long COVID or post-acute sequelae
of coronavirus disease 2019 (COVID-19), a condition characterized by the
persistence of COVID-19 symptoms beyond 3 months. The long-term impact of COVID-19 on cardiovascular (CV) health and
mortality is also emerging as a major global concern.
Definit...
The New England Journal of Medicine
(NEJM):
Locally
advanced rectal cancer is typically managed with multimodal therapy, including
chemotherapy, radiation, and surgery.
Owing to
the complications of surgery and the high frequency of pathological complete
response, interest in organ-sparing nonoperative management is increasing....
The human
pancreas is a target of severe acute respiratory syndrome coronavirus 2
(SARS-CoV-2). New-onset hyperglycaemia and insulin resistance have been
reported in patients with coronavirus disease-2019 (Covid-19) without history
of diabetes.
However,
it is unclear whether such metabolic alterations are transient or whether
individu...
