The role of Dexlansoprazole in the management of Gastro-Esophageal Reflux Disease (GERD)

Gastro-Esophageal Reflux Disease (GERD) is a chronic disorder of the digestive system caused by the lower esophageal sphincter not closing properly. This can allow stomach acid, bile into esophagus, causing inflammation and, in some cases, tooth erosion.

Heartburn and acid regurgitation are the main symptoms of GERD, though some people have GERD without heartburn. When symptoms are chronic, GERD can interfere with sleep and other daily functions, as well as progress to more serious conditions.

Dexlansoprazole DDR is well tolerated and can be taken with or without food.


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Highly Effective PPI in GERD

Dexlansoprazole Dual Delayed Release (DDR) has been shown to be highly efficacious in healing erosive esophagitis, maintaining healed esophageal mucosa in patients with erosive esophagitis and controlling symptoms of patients with nonerosive reflux disease (NERD).

Recent studies have also demonstrated that Dexlansoprazole DDR is highly effective in improving nocturnal heartburn; gastroesophageal reflux disease (GERD) related sleep disturbances and bothersome regurgitation.

Dual Delayed Release (DDR) formulation

Dexlansoprazole modified-release (MR) is the R-enantiomer of lansoprazole and is currently the only proton-pump inhibitor (PPI) with a novel Dual Delayed Release (DDR) formulation.

Dexlansoprazole has a dual delayed release (DDR) technology which was designed to prolong the plasma concentration time profile in order to improve symptoms control and esophageal mucosal healing, using a once-daily dose. 

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This is for informational purposes only. You should consult your clinical textbook for advising your patients.
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