Efficacy of Azole Antifungal in Treatment of Tinea (Pityriasis) Versicolor

PubMed Central: Published on January 2019

Tinea (Pityriasis) Versicolor is a common, chronic, superficial fungal infection caused by Malassezia spp. It is characterised by hyperpigmented, hypopigmented macules and patches on the face, upper trunk, back, chest paralleling the density of sebaceous gland.

Several topical and systemic antifungal agents are effective against pityriasis versicolor. However, recurrence is common. Therefore, approaching an effective, safe and affordable treatment regimen should be taken in consideration.

TAKE HOME MESSAGE:

This study aimed to assess and compare the efficacy and the safety of oral fluconazole combined with foam ketoconazole, oral itraconazole and foam ketoconazole alone.

In conclusion, topical combined with systemic therapy is effective against tinea versicolor, especially extensive disease, frequent relapses, or history of failed topical treatment.

In the current study, authors found the highest mycological cure rate, 62.4%, with a single oral dose of fluconazole 300mg along with ketoconazole 2% twice a week, higher than with itraconazole 200 mg daily for one week (35.3%) and ketoconazole (37.5%).

It was reported in this study that the most effective regimen for Pityriasis Versicolor patients is fluconazole 300 mg per week combined with ketoconazole 2% twice a week for 2 weeks.

Available Brand

Doctors Liked to Read More

Abstract

Abstract

Aim: Compare itraconazole alone, fluconazole combined with ketoconazole and ketoconazole in the treatment of patients with pityriasis versicolor.

Material and methods: A group of 240 pityriasis versicolor patients (confirmed with KOH and culture) were classified into 3 groups: Fluconazole 300 mg a week and 2% ketoconazole foam twice a week for 2 weeks (Category I), Itraconazole 200 mg daily for one week (category II); Ketoconazole 2% foam daily for 2 weeks (Category 3). Clinical (colour of macule, scale, pruritus) and mycological assessment were done after 4 weeks of therapy.

Results: After 4 weeks of treatment, clinical cure was observed in 62.4% (Category I), 36.3% (Category II) and 37.5% (Category III).

Conclusion: It was reported in our study that the most effective regimen for PV patients is fluconazole 300 mg per week combined with ketoconazole 2% twice a week for 2 weeks.

Rate This Article