Featured
Parkinson's disease (PD) is a progressive, neurodegenerative
disorder of aging that affects both motor and cognitive function. The etiology
of PD is mostly unknown, but it likely involves both genetic and environmental
factors.Recognizing early symptoms of Parkinson'sNonmotor symptoms:Nonmotor symptoms are common in early Parkinson disease. The...
A Report
of the American Academy of Neurology (AAN) Guideline Subcommittee:Levodopa preferred as initial dopaminergic therapy for motor symptoms in
patients with early Parkinson disease.Parkinson
disease (PD) is a neurodegenerative disorder that causes both motor and
nonmotor symptoms and increases in prevalence with age. Motor symptoms in the...
JAMA NeurologyTAKE-HOME MESSAGE
Evidence is rapidly accumulating of
the benefit of exercise and physical activity in Parkinson disease (PD). The
authors conducted a nationwide population-based cohort study of 10,699
individuals with PD, evaluating the association of physical activity (obtained
from self-reported structured questionnaires...
Motor symptoms are those that
affect movement of the body. These are the cardinal symptoms of PD. The main
motor symptoms of PD are tremor, slowness of movement (bradykinesia), stiffness
(rigidity), and poor balance (postural instability). These symptoms are usually
mild in the early stages of the disease. PD patients show additional mo...
NICE guideline:
Suspect
Parkinson's disease in people presenting with tremor, stiffness, slowness,
balance problems and/or gait disorders.
If
Parkinson's disease is suspected, refer people quickly and untreated to a
specialist with expertise in the differential diagnosis of this condition.
Clinical diagnosis
Diagnose
Parkinso...
Introduction
Parkinson’s disease (PD) is a
neurodegenerative disease resulting from progressive death of the dopaminergic
neurons in the brainstem, particularly the substantia nigra pars compacta
(SNc). Besides the hallmark motor symptoms (hypokinesia, rest tremor, rigidity,
and postural instability), PD patients have non-motor symptoms...
JAMA Neurology:
Early and prodromal features of
Parkinson disease (PD) have increasing relevance as the quest for potential
disease-modifying therapies is expanding.
KEY TAKE-HOME MESSAGE
Question What
are the prediagnostic manifestations of Parkinson disease (PD) presented in the
primary care setting?
Findings This
case-contr...
Take Home Messages:
Authors propose a new conceptual
model for PD pathogenesis, in which disease-associated factors are divided into
three categories: triggers, facilitators, and aggravators.
Triggers are agents or events that begin the disease process; these
factors are necessary but insufficient for PD to develop.
Facilitators ar...