Key Information: Progesterone is essential for the maintenance of a healthy pregnancy. Progesterone is frequently prescribed to patients presenting with per vaginal (PV) bleeding in early pregnancy and a history of recurrent pregnancy loss. Any defect in the secretion of human chorionic gonadotropin or progesterone is associated with...

The Journal of Obstetric and Gynecological Research: Miscarriage is the most common cause of early pregnancy loss in the first 24 weeks and one of the most common complications in early pregnancy. An estimated 15% to 20% of pregnancies will end in a miscarriage, with 25% of women experiencing a miscarriage in their lifetime. Women can b...

The British Medical Journal (BMJ): Increasing evidence suggests that reproductive factors unique to women are associated with a greater risk of death from non-communicable diseases. Even if reproductive events do not increase the risk of death from non-communicable diseases, they could be useful as an early stress test of underlying risk...

Successful oocyte implantation and a favorable pregnancy outcome rely on optimal progesterone levels. Therefore, progesterone deficiencies associated with infertility and miscarriages have commonly been treated with progestogens that mimic the activity of progesterone. Among those is dydrogesterone, an oral retrosteroid with a structur...

Progesterone maintains pregnancy by enhancing uterine quiescence. During early pregnancy, the syncytiotrophoblast secretes human chorionic gonadotropin (hCG), which stimulates progesterone production in the corpus luteum by preventing regression of this tissue. Low serum hCG or progesterone levels may predict first trimester abortions....