Monkeypox cases have been reported in several countries in Africa such as Congo and Pakistan recently. The World Health Organization (WHO) announced on 14 August 2024 that it declared MPox a ‘public health emergency of international concern. Monkeypox is a viral zoonosis (a virus transmitted to humans from animals) with sym...

JAMA Neurology: Early and prodromal features of Parkinson disease (PD) have increasing relevance as the quest for potential disease-modifying therapies is expanding. KEY TAKE-HOME MESSAGE Question What are the prediagnostic manifestations of Parkinson disease (PD) presented in the primary care setting? Findings This case-contr...

Take Home Messages: Authors propose a new conceptual model for PD pathogenesis, in which disease-associated factors are divided into three categories: triggers, facilitators, and aggravators. Triggers are agents or events that begin the disease process; these factors are necessary but insufficient for PD to develop. Facilitators ar...