Treatment of Depression and GAD

Treatment should be tailored to a specific diagnosis. A treatment plan for a diagnosis of depression and an anxiety disorder should be designed to help a person manage and reduce the symptoms of both disorders, often at the same time.





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Therapy can be tailored to an individual so that it works to reduce the symptoms of both disorders.

Several forms of psychotherapy are effective. Of these, cognitive-behavioral therapy (CBT) works to replace negative and unproductive thought patterns with more realistic and useful ones. 

Medications can also be useful. Symptoms of depression and anxiety disorders often occur together, and research shows that both respond to treatment with selective serotonin reuptake inhibitor (SSRI) such as Escitalopram.

Escitalopram have been proved effective in treating depression, generalized anxiety disorders, including obsessive-compulsive disorder (OCD), panic disorder, and social phobia.


Significant: Withdrawal syndrome, anxiety, suicide-related events, worsening of depressive symptoms, hypomania or mania, bleeding abnormalities (e.g. ecchymoses, purpura, haematoma, epistaxis), akathisia, QT interval prolongation, ventricular arrhythmia, torsade de pointes, mydriasis, narrow-angle glaucoma, bone fractures, sexual dysfunction.

Rarely, hyponatraemia.

Gastrointestinal disorders: Nausea, diarrhoea, vomiting, constipation, dry mouth.
General disorders: Fatigue, pyrexia.
Metabolism and nutrition disorders: Decreased or increased appetite, increased weight.
Musculoskeletal and connective tissue disorders: Arthralgia, myalgia.
Nervous system disorders: Headache, dizziness, paraesthesia, tremor.
Psychiatric disorders: Restlessness, abnormal dreams, insomnia, somnolence.
Reproductive system and breast disorders: Decreased libido, anorgasmia, ejaculation disorder, impotence.
Respiratory, thoracic and mediastinal disorders: Sinusitis, yawning.
Skin and subcutaneous tissue disorders: Increased sweating.

Potentially Fatal: Serotonin syndrome, suicidal ideation or behaviour, haemorrhage.

Pregnancy

There are no adequate and well-controlled studies in pregnant women; therefore, use during pregnancy only if the potential benefit justifies the potential risk to the fetus

Lactation

Escitalopram is excreted in human breast milk

Caution should be exercised and breastfeeding infants should be observed for adverse reactions when administered to a nursing woman


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This is for informational purposes only. You should consult your clinical textbook for advising your patients.