Treatment for Pityriasis (Tinea) Versicolor

Pityriasis versicolor, also known as tinea versicolor, is a common, benign, superficial fungal infection of the skin. Tinea versicolor is not considered contagious.

Pityriasis versicolor is caused by Malassezia fungus, also known as Pityrosporum. It is a component of normal skin flora. It is more common in warm and humid conditions.

Clinical Features

Patients with pityriasis versicolor present with multiple, well-demarcated, oval, finely scaling patches or plaques. Skin lesions may be hypopigmented, hyperpigmented, or erythematous and occasionally become confluent and widespread.

The most frequently affected sites are the trunk, neck, and proximal extremities. The face also may be affected, particularly in children.



Pityriasis versicolor skin lesions are usually asymptomatic or slightly pruritic. However, severe pruritus can be present in very warm and humid conditions.

Evaluation

Diagnosis of pityriasis versicolor is usually easily made on the basis of its characteristic clinical presentation (hyperpigmented or hypopigmented, finely scaling patches or plaques).

The diagnosis is confirmed by microscopic examination of scales soaked in potassium hydroxide examination. A Wood light examination reveals golden-white fluorescence.

Treatments

Topical medications are considered the first-line therapy for pityriasis versicolor.

Topical treatments are divided into-

Nonspecific antifungal agents (sulfur-salicylic shampoo 2%, selenium sulfide 2.5% shampoo and zinc pyrithione soap 2% daily) that primarily remove dead tissue and prevent further invasion, and

Specific antifungal drugs that have fungicidal or fungistatic effects.

Antifungal agents include imidazole (clotrimazole 1%, ketoconazole 2%), ciclopirox olamine 1%, and allylamine (terbinafine 1%).

Foaming solutions in shampoo are preferable to creams because creams are oilier and more difficult to apply, especially in widespread areas.


Ketoconazole (ketoconazole 2% shampoo daily for 2 weeks) is the most common topical treatment used to treat pityriasis versicolor to cover large surface areas.

Oral medications are viewed as a second-line of treatment for pityriasis versicolor in the event of widespread, severe, recalcitrant or recurrent cases. Systemic therapies include itraconazole (200 mg daily for seven days) and fluconazole (150 to 300 mg weekly dose for 2 to 4 weeks)

In cases of recurrent pityriasis versicolor, maintenance therapy may be necessary.

Doctors Liked to Read More

Background: Pityriasis versicolor (PV), also known as tinea versicolor, is caused by Malassezia species. This condition is one of the most common superficial fungal infections worldwide, particularly in tropical climates. PV is difficult to cure and the chances for relapse or recurrent infections are high due to the presence of Malassezia in the normal skin flora. This review focuses on the clinical evidence supporting the efficacy of antifungal treatment for PV.

Method: A systematic review of literature from the PubMed database was conducted up to 30 September 2014. The search criteria were "(pityriasis versicolor OR tinea versicolor) AND treatment", with full text available and English language required.

Conclusions: Topical antifungal medications are the first-line treatment for PV, including zinc pyrithione, ketoconazole, and terbinafine. In cases of severe or recalcitrant PV, the oral antifungal medications itraconazole and fluconazole may be more appropriate, with pramiconazole a possible future option. Oral terbinafine is not effective in treating PV and oral ketoconazole should no longer be prescribed. Maintenance, or prophylactic, therapy may be useful in preventing recurrent infection; however, at this time, there is limited research evaluating the efficacy of prophylactic antifungal treatment.

Read In Details


https://www.ncbi.nlm.nih.gov/books/NBK482500
https://pubmed.ncbi.nlm.nih.gov/29376896
https://www.merckmanuals.com/professional/dermatologic-disorders/fungal-skin-infections/tinea-versicolor

This is for informational purposes only. You should consult your clinical textbook for advising your patients.