The authors of this study evaluated the association between weight loss and total knee or hip replacement for osteoarthritis among middle-aged and older adults with overweight or obesity. Compared with maintaining a stable weight, weight loss of >7.5% was associated with a reduced risk of total knee but not total hip replacement.

A weight loss target of >7.5% was associated with a reduced risk of total knee replacement among individuals with overweight or obesity and subsequent weight gain should be avoided.

Reference:

Int J Obes (Lond) 2021 Aug 01;45(8)1696-1704, X Jin, AA Gibson, J Gale, F Schneuer, D Ding, L March, A Sainsbury, N Nassar

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