Effects of Metformin and Intensive Lifestyle Interventions on the Incidence of Kidney Disease in Diabetes

Journal of Diabetes and its Complications: September 2023

Kidney disease is a diabetes-related complication and diabetes is the most common cause of end-stage kidney disease (ESKD) in the world.

This study analyzed the incidence of kidney disease in the Diabetes Prevention Program Outcomes Study.


After 21 years of randomization in the program, diabetes development was decreased in both the intensive lifestyle management and metformin groups compared with the placebo group.

There was no difference in the incidence of kidney disease between the two intervention groups; however, kidney disease was more common among patients with incident diabetes than among those without diabetes.

Metformin was beneficial for kidney disease in younger participants and potentially harmful for older participants.

There was no difference in the development of kidney disease among the intervention groups. However, the incidence of kidney disease development increased among participants with diabetes.

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