Cefuroxime plus Clavulanic acid: Effectively treat Resistant Bacteria

Cefuroxime is a 2nd generation cephalosporin group of broad-spectrum β-lactam antibiotic.

Clavulanic acid is a beta lactamase inhibitor used to enhance the effectiveness of beta lactam antibiotics. Clavulanic acid does have some degree of bacterial activity; its principal role is as a beta-lactamase inhibitor.

Used in combination with the beta-lactam antibiotics, it has become one of the most prescribed antibiotics prolonging the effective life of antibiotics.

Thus, the combination of cefuroxime and clavulanic acid (ß -lactamase inhibitor) provides a solution for treatment of bacterial infections caused by beta lactam resistant pathogens.

Available Brand

Doctors Liked to Read More

What are strains of bacteria they are active?

Cefuroxime-Clavulanate has been demonstrated to be active against most strains of the following microorganisms:

Aerobic Gram-Positive Microorganisms:
Staphylococcus aureus

Streptococcus pneumonia

Streptococcus pyogenes

Aerobic Gram-negative Microorganisms:
Escherichia coli
Haemophilus influenzae
Haemophilus parainfluenzae
Klebsiella pneumoniae
Moraxella catarrhalis
Neisseria gonorrhoeae

Spirochetes:
Borrelia burgdorferi

Key Points

Key Points:

Cefuroxime is generally well tolerated and side effects are usually transient.

Unlike other second generation cephalosporins cefuroxime can cross the blood-brain-barrier.

Cefuroxime "follow-on" therapy produces clinical and bacteriological efficacy equivalent to that of amoxicillin/clavulanic acid, with the advantage of twice daily oral administration.

Most active cephalosporin for beta-lactamase-producing Haemophilus influenzae, organism that causes respiratory tract infections such as otitis media, bronchitis and sinusitis

Cefuroxime serum levels may be increased if taken with food or dairy products (from 37% to 52%)