The British Journal of Dermatology: Published: 16 September 2024

Retinoids, widely used in dermatology for treating acne and various skin conditions, have raised concerns regarding potential side effects, particularly sexual dysfunction. Although retinoids are effective in managing skin conditions, their association with sexual dysfunction is becoming an area of interest.

TAKE-HOME MESSAGE

This systematic review assessed data regarding sexual dysfunction associated with the use of retinoids. A total of 11 studies were included, with three studies reporting on etretinate, two on acitretin, and six on isotretinoin.

More than 300 cases of post-retinoid sexual dysfunction were reported across the studies. Vulvovaginal dryness, dyspareunia, vaginal bleeding, and loss of libido were the most common effects reported by females. Up to 40% of women experienced vulvovaginal symptoms, and these symptoms seem to be dose-dependent. 

Some of the potential connection between retinoids and sexual dysfunction may be explained by retinoid-induced xerosis and increased skin fragility.

There was conflicting data across studies regarding the risk of erectile dysfunction in males treated with isotretinoin.

Although post-retinoid sexual dysfunction should be discussed with patients before starting therapy, further studies are warranted to determine whether there is a true association.

CONCLUSION

Healthcare providers should be vigilant, informing patients of potential risks while continuing to explore safer therapeutic options. Open communication and patient education are key in ensuring a balanced approach to treatment and patient well-being.