Social Science Research Network (SSRN) Elsevier Journal: Published on April, 2023

Dysfunctional uterine bleeding (DUB) is defined as bleeding from the uterine corpus that is abnormal in regularity, volume, frequency, or duration and occurs in the absence of pregnancy.

Dysfunctional Uterine Bleeding (DUB) is defined as abnormal uterine blood loss in the absence of organic genital tract disease. It refers to any variation in uterine bleeding, including menstrual cycle disturbances, rhythmic and non-rhythmic uterine bleeding, and revision in the amount or duration of menstruation loss.

However, it tends to most generally refer to excessive normal menstrual bleeding or vital menorrhagia.

TAKE HOME MESSAGE

Methylprogesterone (MPA) and Norethisterone (NE) are a sort of female hormone (progestin).

The two drugs are given in different doses, duration, and frequencies, NE (5mg × 25 days ie; 2 stat, 1-1-1 × 3 days, 1-0-1 × 21 days) and MPA (10mg × 21 days, 1-0-1).

The majority of patients respond favorably to medical treatment. Norethisterone and Medroxyprogesterone are both effective in treating these cases.

DUB was more frequent in women over the age of 35, due to a rise in uterine mean volume. DUB is most common in women with a high BMI (25-29.9-overweight), and it is affected by delayed endometrial repair.

Norethisterone has a much stronger effect, as per this study. Thus, Norethisterone was discovered to be more effective than Medroxyprogesterone in lowering menstrual loss. Neither drug has any significant side effects or complications.