5 mm Hg reduction of systolic blood pressure reduced the risk of major cardiovascular events
Results from the meta-analysis of 48 trials demonstrated
that even a small reduction in systolic blood pressure (just 5 mm Hg) could
reduce the risk of cardiovascular events by 10%, and even at normal or
high-normal blood pressure values.
These findings suggest that a fixed degree of pharmacological blood pressure lowering is similarly effective for primary and secondary prevention of major cardiovascular disease, even at blood pressure levels currently not considered for treatment.
Physicians communicating the indication for blood pressure lowering treatment to their patients should emphasise its importance on reducing cardiovascular risk rather than focusing on blood pressure reduction itself.
Note: Doctors still need to use judgment in
deciding how intensively to lower BP, and of course, patient tolerance to
treatment is a very important limiter to this approach.
Doctors Liked to Read More
Arvanitis M, Qi G, Bhatt DL, et al. Linear and nonlinear
Mendelian randomization analyses of the association between diastolic blood
pressure and cardiovascular events: the J-curve revisited. Circulation.
2021;143(9):895-906. https://www.ahajournals.org/doi/10.1161/CIRCULATIONAHA.120.049819
Whelton SP, McEvoy JW, Shaw L, et al. Association of normal
systolic blood pressure level with cardiovascular disease in the absence of
risk factors. JAMA Cardiol. 2020;5(9):1011-1018. https://jamanetwork.com/journals/jamacardiology/article-abstract/2766469
https://www.practiceupdate.com/content/pharmacological-bp-lowering-for-primary-and-secondary-prevention-of-cvd-across-different-bp-levels/117758/11/0/1
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