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A Systematic Review and
Meta-analysisGastroesophageal reflux disease (GERD) is a chronic digestive
disorder resulting from the reflux of gastric contents into the esophagus that
is often accompanied by troublesome symptoms of heartburn, acid regurgitation,
or other extra-esophageal symptoms such as chest pain, chronic cough,
hoarseness or glob...
Clinical Gastroenterology and Hepatology
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This review presents best practice
advice statements to help healthcare providers in the treatment of patients
with gastroesophageal reflux disease (GERD).
To optimize care and response,
diagnostic testing should be personalized and management should be tailored to
the ind...
Proton
pump inhibitors (PPIs) are among the most commonly used medications in the
world. Developed for the treatment and prevention of acid-mediated upper
gastrointestinal conditions, these agents are being used increasingly for
indications where their benefits are less certain.
PPI over prescription
imposes an economic cost and contri...
British Medical Journals (BMJ):
IntroductionProton pump inhibitors (PPIs) are
commonly prescribed drugs indicated for several gastric conditions, including
peptic ulcer disease, GERD and Barrett’s oesophagus.
Recent evidence suggests that PPIs
are commonly overprescribed, either in patients without an evidence-based
indication fo...
The American Journal of Gastroenterology
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This nested case-control study
examined adults with gastric, liver, colorectal, and pancreatic cancers and use
of PPI for ≥2 years. Cancer risks for PPI dose and duration were also
evaluated.
While exploratory analysis found
an increased cancer risk for PPI use ≥10 years,...
Proton pump inhibitor (PPI) was commonly used worldwide, to
treat peptic ulcer disease (PUD), gastroesophageal reflux disease (GERD), Helicobacter
pylori infection, or prevent side effects of glucocorticoids or
non-steroidal anti-inflammatory drugs (NSAIDs). However, PPI agents were also
overused by off label indication, excessive dosage an...
The British Medical Journal (BMJ):
British Society of
Gastroenterology (BSG) and British Society of Paediatric Gastroenterology,
Hepatology and Nutrition (BSPGHAN) joint consensus guidelineThese joint consensus guidelines
from the British adult and paediatric gastroenterology societies utilize the
GRADE methodology to make recommendatio...
Gastrointestinal (GI) bleeding is
the most common GI diagnosis necessitating. Upper GI bleeding (UGIB) refers to
bleeding originating from sites in the esophagus, stomach, or duodenum.AbstractThe American Journal of
Gastroenterology society performed systematic reviews addressing predefined
clinical questions to develop recommendations with the...
The American Journal of GastroenterologyTAKE-HOME MESSAGE
In a study evaluating sleep position and nocturnal
gastroesophageal reflux, the sleep positions of 57 individuals referred
for ambulatory pH impedance were measured and analyzed. The left lateral
position was associated with significantly shorter acid exposure time than...
Esomeprazole is the first proton
pump inhibitor to be developed as an optical isomer for the treatment of
acid-related diseases. One-week triple therapy with esomeprazole provides
effective eradication of Helicobacter pylori in duodenal ulcer disease.Study Design:Study compared the efficacy of
both esomeprazole and omeprazole, in combination wi...
Esomeprazole is the S-isomer of
Omeprazole and reduces gastric acid secretion through a specific targeted
mechanism of action. It is a specific inhibitor of the acid pump in the
parietal cell. Esomeprazole works better to lower acidity in the gut and
improve symptoms of GERD compared to omeprazole. How?Find out below: RemoveAvailable Brand
Reflux esophagitis is an
esophageal mucosal injury that occurs secondary to retrograde flux of gastric
contents into the esophagus. Clinically, this is referred to as
gastroesophageal reflux disease (GERD).Fig: EsophagitisWhich PPI is Superior?Some of the present study demonstrated that Esomeprazole gave faster symptom relief
in patients with R...
