Esomeprazole provides effective eradication of Helicobacter pylori in duodenal ulcer disease
Esomeprazole is the first proton pump inhibitor to be developed as an optical isomer for the treatment of acid-related diseases. One-week triple therapy with esomeprazole provides effective eradication of Helicobacter pylori in duodenal ulcer disease.
Study Design:
Study compared the efficacy of
both esomeprazole and omeprazole, in combination with amoxicillin and
clarithromycin, for the eradication of H. pylori in patients with
duodenal ulcer (duodenal ulcer) disease.
The study was a double-blind,
randomised, parallel-group study conducted at 56 centres in Europe and Canada,
performed according to both internationally accepted guidelines for clinical
trials in Helicobacter pylori infection.
Four hundred and forty eight duodenal ulcer patients with Helicobacter pylori infection, confirmed by 13C-urea breath test (UBT), and no current ulcer, were randomised to double-blind treatment with esomeprazole 20 mg twice daily or omeprazole 20 mg b.d., in combination with amoxicillin 1g b.d. and clarithromycin 500 mg b.d. for 1 week. A negative UBT at both 4 and 8 weeks after completing therapy indicated successful H. pylori eradication.
Study Results:
Esomeprazole-based triple therapy
for 1 week is highly effective in eradicating H. pylori infection in
duodenal ulcer disease, offers comparable efficacy to omeprazole-based therapy,
and is well tolerated.
Early clinical studies have shown
that both esomeprazole 40 mg and 20 mg achieve greater and more sustained acid
control than omeprazole 20 mg, with a similar tolerability and safety profile.
Moreover, esomeprazole shows a
more rapid onset of acid-suppressant effect than omeprazole and less inter-individual
variation in acid control, thereby providing greater predictability
of response.
The results for the esomeprazole-based combination demonstrate high cure rates, coupled with good tolerability and high patient compliance.
Source:
https://pubmed.ncbi.nlm.nih.gov/11742194/
https://onlinelibrary.wiley.com/doi/full/10.1046/j.1365-2036.2000.00911.x
https://emedicine.medscape.com/article/2172395-overview
https://www.racgp.org.au/afp/2014/may/helicobacter-pylori-eradication#ref-9
Note: For informational purposes only. Consult your
textbook for advising your patients.
Comments
You must login to write comment