Cefuroxime plus Clavulanate makes patient-care easy for treating bacterial infections

Cefuroxime is the 2nd generation cephalosporin group of broad-spectrum β-lactam antibiotic. And Clavulanic acid is a beta lactamase inhibitor used to enhance the effectiveness of beta lactam antibiotics.

CEFUROXIME- CLAVULANATE is indicated for the treatment of patients with mild to moderate infections caused by susceptible strains of the designated microorganisms in the conditions listed below:

Upper respiratory tract infections including:

· Pharyngitis/tonsillitis

· Acute bacterial otitis media

· Acute bacterial maxillary sinusitis

Lower respiratory tract infections including:

· Pneumoniae

· Acute bacterial exacerbations of chronic bronchitis

· Secondary bacterial infections of acute bronchitis

Uncomplicated skin and skin-structure infections

Uncomplicated urinary tract infections

Uncomplicated gonorrhea (urethral and endocervical)

Early lyme disease (erythema migrans)

Surgical prophylaxis

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Mechanism of Actions

Cefuroxime has bactericidal activity against a wide range of common pathogens, including beta-lactamase producing strains. The bactericidal action of cefuroxime results from inhibition of cell wall synthesis by binding to essential target proteins. Cefuroxime has good stability to bacterial beta-lactamases.

Clavulanic acid is a naturally derived beta lactamase inhibitor produced by Streptomyces clavuligerus. Clavulanic acid binds to and inactivates them thus preventing the destruction of cefuroxime that is a substrate for this enzyme. It has poor intrinsic antimicrobial activity, but it is an irreversible binder of ß-lactamases produced by a wide range of gram positive and gram negative microorganism.